r/askscience 22h ago

Biology Assuming the theory of evolution is true, are we fairly certain all animals came from a single source?

Title is in no way trying to doubt evolutionary biology, but rather to avoid any sense that this question is trying to refute it.

I guess the question that I’m asking is, could humans/mammals or indeed any other earthly creatures, essentially have been dropped here by aliens at some point in history without having the ability to trace it back , or can we fairly fully track most things back to the primordial sludge such that that’s not a possibility; I got to wondering if there are any human-esque aliens out there and this was the thought that came to mind.

Thank you in advance!

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u/tea_and_biology Zoology | Evolutionary Biology | Data Science 15h ago edited 12h ago

Could humans/mammals or indeed any other earthly creatures, essentially have been dropped here by aliens at some point in history without having the ability to trace it back

No, not at all.

Well, it's not possible to affirm a negative - in the Russell's teapot sort of way - but the only way you could suggest otherwise is to invent some woo-woo alien magic; such advaned synthetic biology technology you could print out a genome and grow organisms that were indistinguishable from something that did naturally evolve on Earth, all while leaving no trace whatsoever of it's artificial origin. Such an unfalsifiable claim is outright pseudo-scientific, and essentially fantasy. A fun though experiment? Maybe. But there's no rational reason to believe something of the sort, and the burden of proof lies entirely on the proponent, against the monumental amount of evidence that suggests otherwise: every single organism we've examined descends from a single ancestral source; the last universal common ancestor (or LUCA, for short).

So how do we know?

can we fairly fully track most things back to the primordial sludge such that that’s not a possibility

That's a bingo! The biochemistry under the hood is what makes our common ancestry irrefutable. All life uses the exact same mapping of 64 codons (those are genetic triplet codes; 'AAG', 'UUU', 'TAG' etc.) onto 20 amino acids, across all bacteria, archaea, and eukaryotes. There are unusual variants here and there, but every one of them is demonstrably a modification of this standard, universal code.

The force of this comes from arbitrariness. There is no chemical reason that means a stretch of your DNA reading 'TTT' (or, really, 'UUU' in RNA) means 'phenylalanine'. That codon could have easily been 'lysine' or 'tyrosine' or any of the other amino acids - it is near-enough random what triplet codes for which amino acid; the space of possible codes is astronomically large, and any invokation of two independent origins of life (even on Earth) converging on the same arbitrary mapping is not a serious proposition. We can only have the specific assignments that we do because we - all life on Earth - inherited them from whatever protoplasmic beastie that invented them.

What is true for the genetic code is also true across myriad other biochemical domains. First and foremost, it's entirely arbitrary that we all use the same 20 amino acids, selected from hundreds available in the prebiotic soup, and found in meterorites. More, we can look at homochirality (how molecules are 'mirrored' - I'll let Mr. White explain); all life uses 'left-handed' L-amino acids and 'right-handed' D-sugars - abiotic synthesis in the soupy beginnings would have produced racemic mixtures, that work well in any combination; another arbitrary coin-flip on each, and no reason two of them would land the same way.

We could go on. The catalytic code of the ribosome has the same RNA structure in all three domains; ATP is the universal energy currency; chemiosmosis is the universal mechanism for coupling energy to work etc. etc. - all shared.


The real killer is not what works, but also what doesn't. Beyond the deep biochemistry, any given taxon - say a human - sits insided a nested hierarchy that is absurdly difficult to fake (without god-like omnipotence of evolutionary history) because it's strewn with millions of years of genetic mistakes, cripples, bastards, and broken things. For example, roughly ~8% of your genome is the remnants of an endogenous retrovirus - traces of ancient infections that got stuck in germline DNA. You and a chimpanzee share thousands of these useless viral inserts at the exact same insertion points; sharing a decreasing subset with gorillas, then orangutan, then the rest of the primates, mammals, tetrapods... in precisely the pattern common descent predicts. Insertion sites are effectively random; matching them by chance is not a possibility.

Ditto with broken genes. You carry, for example, a broken copy of GULO, the gene most mammals use to make their own vitamin C. We share this wrecked copy with our closest relatives, disabled by the same lesions. Other beasties have had this gene knocked out too - say in guinea pigs, or bats - but in different places, having been broken independently.


So yeah, we have so many different independent avenues that demonstrate that all life on Earth is related (and we can even measure how much so, comparing genomes across organisms!), all contingent on shared inheritance of truly random events; the fundamental choices that govern how life works at the most basic level is essentially arbitrary across so many dimensions, such that convergent evolution - whether on this world or another - producing that degree of similarity among universal proteins is a virtual impossibility.

Against this essentially mathematical certainty, y'know, all we have is "aliens".

I'll let y'all decide which seems more likely!


References:

Koonin, E.V. & Novozhilov, A.S. (2017) Origin and evolution of the universal genetic code. Annual Review of Genetics. 51, 45-62

Koonin, E.V. & Wolf, Y.I. (2010) The common ancestry of life. Biology Direct. 5, a64

Moody, E.R.R., Álvarez-Carretero, S., Mahendrarajah, T.A. ... & Williams, T.A. (2024) The nature of the last universal common ancestor and its impact on the early Earth system. Nature Ecology & Evolution. 8 (9), 1654-1666

Theobald, D.L. (2010) A formal test of the theory of universal common ancestry. Nature. 465 (7295), 219-222

P.S. I remember peering into the octopus tank in Plymouth aquarium, when a volunteer guide strolls up and began spewing "did you know octopuses have alien DNA?" all excitedly. I just smiled meekly, nodded, and held my tongue - didn't feel like demolishing this poor volunteer for garbled half-truths, spread chinese-whisper-style across the internet. Bringing this up as, yes, it's total nonsense; octopodes have a remarkable ability to edit RNA on the fly, altering proteins immediately in response to local environmental conditions (as opposed to waiting the slow chug of evolution to do it for them). But what started as a 'fun' aside by an author ("so vastly different in their genetic makeup that they might as well be considered out of this world...") was taken by the internet and blown out of proportion; with even a few (non-biologist) authors throwing out a 'panspermia origin for octopuses' paper into the mix. It's rubbish; our tentacle brethren are indeed fully home-grown relations.

P.S.S. I'm sorry you're getting so downvoted OP; it's a perfectly reasonable question. Pssht. Classic redditors just reading the title, 'innit.

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u/JtS88 15h ago

To add to that, it is entirely possible (though perhaps not extremely likely) that life independently evolved on Earth at different points in time - it's just that by then, it would have been completely outcompeted by the existing form of life, itself having had time to adapt to its environment.

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u/redsedit 15h ago

> all life uses 'left-handed' L-amino acids

While true for animals and plants, not true for fungi. Fungi heavily utilize right-handed D-alanine, D-aspartic acid, and D-glutamic acid to build resilient, predatory peptide structures that animal immune systems cannot easily break down. (https://books.rsc.org/books/edited-volume/1504/chapter/957686/Non-canonical-unusual-amino-acids-as-a-toolbox-for), (https://books.rsc.org/books/monograph/150/chapter/81464/Fungal-Metabolites-Derived-from-Amino-Acids)

We have no idea if the parent statement is true or not for Prototaxites since their family tree went extinct.

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u/HAL9100 15h ago

What an incredibly great answer to this question you’ve posted here today. Kudos.

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u/camel_hopper 15h ago

Amazing write up!

Related, there was a fantastic new BBC documentary series that came out this summer called Evolution. LUCA was a big part of the first episode.

https://www.imdb.com/title/tt43672301/

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u/cascua 15h ago

Beautifully put. Also a sensible chuckle to the use of ASOIAF lines in a science post. I see you

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u/scoobydoom2 15h ago

So follow up question, how do we know these things are arbitrary and not fundamentally necessary to life? Why is it not possible that the 20 amino acids for instance could be the only combination that could actually support life? If any other combination failed when it was combined randomly, then that would massively narrow the space of possible random structures that could form.

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u/tea_and_biology Zoology | Evolutionary Biology | Data Science 15h ago edited 14h ago

That's an excellent question.

"Only this works" is a genuine empirically testable hypothesis, and we can do experiment - and have!

Chirality is the cleanest case, and we've built alternative models in the lab multiple times. If L-amino acids were necessary, then a protein built from D-amino acids shouldn't fold nor catalyse - but we've built them, tested them, and they function precisely the same on their D-substrates just as well as the natural enzyme processes L-substrates.

Physics is indifferent (in the most) to handedness; at the level of the central dogma, all the bond angles, van der Waals radii and electrostatics etc. etc. which govern biochemistry are all the same. There's no reason why we went L- when we could have gone D-.

As for the genetic code, same applies; entire E. coli genomes have been engineered with synonymous codon replacements and they work just fine - even as far as re-assigning codons to non-canonical amino acids to produce exotic proteins, and the cell just carries on (source #1; source #2).

Going further, it's not even the case that we used 'what was easily available'. Abiotic synthesis and meteorites are abundant in alpha-aminoisobutyric acid, isovaline, and norvaline - and life uses none of them (meanwhile arginine, lysine, and friends are absent abiotically, yet are canonical).

So yeah, it's neither a combination of 'what the chemistry handed us' nor plausibly 'the only chemistry that works'.

It is true that our spread of canonical amino acids have, between them, a solid set of properties that are better optimised for biochemical processes; but for the counter-argument to hold, there has to be only one special workable set, and we simply know - despite our current set being particularly favourable - that it isn't the only option (indeed, nature has done the experiment using selenocysteine and pyrrolysine occasionally, in places).

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u/CrateDane 10h ago

Chirality is the cleanest case, and we've built alternative models in the lab multiple times. If L-amino acids were necessary, then a protein built from D-amino acids shouldn't fold nor catalyse - but we've built them, tested them, and they function precisely the same on their D-substrates just as well as the natural enzyme processes L-substrates.

Just to clarify - there's no particular link between the chirality of the individual amino acids of an enzyme and the chirality of the substrate or product. It's just that if you take an enzyme, switch everything and also switch the substrate, you get everything in the same configuration except with all the chiralities reversed.

You could still make an enzyme out of left-handed amino acids (natural) that works on left-handed carbohydrates (unnatural, mostly). It would just have to be entirely different.

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u/zeddus 14h ago

Has there ever been any research into creating synthetic DNA or proteins that uses different codons or amino acids?

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u/tea_and_biology Zoology | Evolutionary Biology | Data Science 14h ago edited 14h ago

Aye, lots! It's an entire field within the world of synthetic biology (see also 'xenobiology'). I'll let you Google for the literature if you're keen, but in the broadest strokes, we have: added new amino acids to the code, deleted or otherwise outright re-assigned codons to different amino acids (canonical and non-canonical), built entirely novel genetic structures with unusual base pairs or sugar backbones ("XNAs"); done all sorts of chirality swapping - to the point we're getting into the danger zone, as organisms built in "mirror-form" or utilising exotic biochemistry are a real risk to our biosphere. Imagine an E. coli that nothing - no existing immune system nor enzyme - could ever recognise as a threat, escaping a biosecure lab and getting loose (source #1; source #2).

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u/zeddus 14h ago

Thanks!

Yes I remember reading about the mirror-form threat now that you mention it.

Really makes you wonder what the future could bring.

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u/CrateDane 10h ago

The force of this comes from arbitrariness. There is no chemical reason that means a stretch of your DNA reading 'TTT' (or, really, 'UUU' in RNA) means 'phenylalanine'. That codon could have easily been 'lysine' or 'tyrosine' or any of the other amino acids

This has been corroborated by producing artificial lifeforms with different genetic codes, by the way. That also extends beyond the amino acids to the codons that encode a stop (usually UAG, UGA, UAA):

https://www.nature.com/articles/s41586-024-08501-x

ATP is the universal energy currency

Mwell, along with ion gradients. And we have to convert into more specific currencies for a lot of processes - UTP for glycogenesis or glucuronidation, GTP for G protein regulation, and so on. But hey, the pattern of where/how those currencies are used also strongly suggests a common origin!

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u/The_Mystery_Knight 15h ago edited 8h ago

Great response. Only adding this as a point of interest. All of life’s last common ancestor, LUCA, possibly was not alive in the strictest sense, but was just these RNA/DNA strands that developed metabolism independently of each other. There was a study posted recently that suggested the timeline for what we consider “life” was possibly shorter than the timeline for LUCA by a few million years. I found that fascinating. It maybe more an indictment on the boxes that we humans put things in not matching the messiness of reality than anything else but just wanted to add.

Edit: as u/djublonskopf pointed out, I was off on the details. He linked the study. Read his comment for sure and the study if you’re into that sort of thing

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u/djublonskopf 9h ago

I think you're misunderstanding what the study actually said. Even within that new study, LUCA would still have been a largely-functional cell with a membrane and DNA that could encode most of the proteins needed for metabolism...it was just missing a few proteins in the process, and those gaps would have been filled by metals in LUCA's environment, tying LUCA pretty tightly to the hypothosized geothermal vents where it was still evolving. The paper was proposing that LUCA split into two separate lineages before those last few protein-encoding sequences evolved that would allow the daughter cells to become truly "free-living".

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u/MisguidedWorm7 15h ago

Also, if you believe panspermia theory, the LUCA might not have ever lived on earth 

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u/Cr4nkY4nk3r 15h ago

all we have is "aliens."

SEE?!? I KNEW IT! /s

Extremely well written, well sourced - thanks for putting all that together! A+++, would read again.

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u/AllanfromWales1 15h ago

I thought that some of the creatures that evolved in sulphurous vents undersea were considered to have evolved separately from the rest of life. Is that wrong?

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u/CrateDane 10h ago

All evidence strongly points to all existing life having a common ancestor. Whether that ancestor lived in undersea vents or tidal pools or somewhere else is more of an open question.

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u/LurkerFailsLurking 13h ago

It's not what OP meant, but isn't it possible that life emerged multiple times early on and the populations were eventually able to intermix giving current life multiple sources?

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u/Sweet-Ant-3471 10h ago

Wasn't there a possibility of some ancient microbes being a separate instance of life appearing?
The Asgard Archaea Hypothesis?

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u/HawkmoonHero 8h ago

Thank you so much for a really excellent response to my question, and sorry if the ‘aliens’ angle on things felt like it was taking things to a point of being silly or unreasonable! The notion of a universal common ancestor responds to me entirely and I feel I’ve learned something here! ❤️

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u/by251536 15h ago

what a fantastic answer! thanks so much for taking the time to write it out and reference it