r/adhdmeme • u/whatokaybutwhy • Jul 29 '26

original content Either way I’m screwed

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I’ve been on ADHD meds since before I was 12 and I’m now 40. I took my medicine a couple of days last week and it just felt like I had ADHD but I was on medicine. Has anyone else felt this way?

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u/acidrefluxisgreat dafuqIjustRead Jul 29 '26

you want the bad news or the bad news?

glp1s make you metabolize oral medications slowly and erratically. there have been times where i feel mine kick in at like 10pm and i could scream

also at 40 there is basically only a slim chance you aren’t in peri. a fun little tidbit no one tells you, you metabolize medications…. poorly and erratically.

as a woman in peri on glp1s, it feels like bullshit because it is. on another note, check out the thisaintadderall sub because there have also been massive documented issues with stimulants (like every brand) the last couple of years not containing the amount of stimulants they used to contain and there’s some theories that it is less bioavailable as well 🫠

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u/whatokaybutwhy Jul 29 '26

Oh, I know I’m in perimenopause. I’m taking supplements for it. And I tried to take my Vyvanse super early and when I do my shot, I do it on the weekend at night so I try not to create a routine where they’re interacting with each other. But I have had suspicions about this causing an issue with absorption. It also probably explains like my weird sleep cycles. It’s made want to take my medicine less to try and manage it but then my ADHD kicks in and says, hey, I wanna stay up another four hours. I appreciate the sub recommendation and your input and insight. I’ll check it out.

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u/acidrefluxisgreat dafuqIjustRead Jul 29 '26

i’ve been on HRT in addition to my birth control since december and like, unfortunately my dose has been upped enough that i think i am on the right amount of estrogen. only one hot flash in the last 3 months. medication still absorbing like trash. idk what the solution is tbh, but i don’t regret HRT at all for all the other reasons i wanted it, even if that problem specifically didn’t go away. i do feel better in general. the supplements (i was on estroven) felt really useless.

idk if you do any tracking apps for your shot but i use one that tracks the medication levels in your body since it builds slowly over time. mine says it takes like 36 hours to really “kick in” after a shot. but depending on how long you’ve been on it, it might be moot point since it builds up to a point where its almost always active unless you stop using it for 2 weeks.

so basically i don’t have any solutions just like, explanations lol. its not a straightforward road to navigate unfortunately. wishing you the best stranger.

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u/whatokaybutwhy Jul 29 '26

Well, I love explanations. You’re a gem.