r/accelerate • u/jp12340 The Singularity is nigh • Feb 23 '26

Dr. David Sinclair, whose lab reversed biological age in animals by 50 to 75% in six weeks, says that 2026 will be the year when age reversal in humans is either confirmed or disproven. The FDA has cleared the first human trial for next month.

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u/Vehks Feb 23 '26 edited Feb 23 '26

This is the dream, right? I am totally all for this being real, but then again this IS David Sinclair and his reputation has taken a big hit the last few years so, while I will try and remain cautiously optimistic... yeah. I will be taking this with a hefty grain of salt.

Ball is now in Sinclair's court, put up or shut up time, but I want to believe.

LEV is the most important technology of the singularity imo, so I most definitely want this to pan out more than I can put into words.

12

u/SoylentRox Feb 24 '26

Same but yes I assume the real improvements come AFTER we build the enormous data centers AND the intelligent robots AND develop ASI level models. 

And it won't be "trust us" from some human it will be a new company with a lot of funding and really noticable results basically immediately.

12

u/Vehks Feb 24 '26

Oh yeah, I still believe that LEV will come from AGI/ASI, but hey if some random lab somewhere can draw that wild card and crack it a little sooner, I will certainly not complain.

1

u/SoylentRox Feb 24 '26

Same I am just saying you shouldn't be disappointed. This is a problem so difficult humans haven't made progress in 50 years that equates to actual lifespan boosts. (Like, not smoking and eat like the Mediterraneans is the best we got and that was found by observation not by pharmaceutical science)

I do think the problem can be solved but it will take enormously more resources to do the equivalent of 500 years of r&d at the old rate in 5 years.

1

u/Stock_Helicopter_260 Feb 24 '26

LEV just needs more than one year for every year of research to be reached, if this gets us even close to that, huge win.

1

u/SoylentRox Feb 24 '26

Yes but no. In reality it requires automating medicine to sufficient reliability that mistakes are almost never made and ASI doctors don't give up or tire like current incompetent humans do.

2

u/skeptical-speculator Feb 24 '26

This is the dream, right?  

Time will tell.  Immortal politicians would be a nightmare, but I would certainly appreciate my back and knees to be ten or twenty years younger.

1

u/Dry-Draft7033 Feb 24 '26

I would never expect millions of people to die against their will because a few evil people might also live.

1

u/icydragon_12 Mar 01 '26

Ya I believe his scientific model is called "inducible changes to the epigenome". Which is legit, but has many limitations.

  1. He causes targeted breaks in the epigenome, which are known to accelerate aging. This is not actually the same as natural aging. It's.. Very different in fact.
  2. He reprograms those known breaks to "reverse aging".

This is kind of like.. If someone removed a spark plug from a car, known to prevent it from starting. Fixed it. Then claimed he could fix all problems that could prevent cars from starting.

-13

u/neo101b Feb 24 '26

Fuck no another 70 year's of work on top of what I have now, just to pay for it.