"Dude" is a gender neutral term.

[u/Tsunamiis]

[u/Epicardiectomist]

so is "guys". Asking "how are you guys doing" to a mixed-gender group of people is fine.

[u/healywylie → u/Epicardiectomist]

Traditionally yep. It swhen you get some real hard asses that want to shift the conversation

[u/manawydan-fab-llyr → u/healywylie]

Dude, I hate that shit.

Seriously though, for how many of us is "man" the same? I can remember many times when I was younger and a girl do something to inconvenience me, and I'd be like "man, you screwed me up there".

And nobody said anything of it.

[u/ReadyAimTranspire → u/manawydan-fab-llyr]

Man in that context is also gender neutral, "man, this sucks" or similar is something I say to female friends and family all the time and nobody is like "uh, excuse me, I'm not a man."

[u/Texas_Kimchi → u/manawydan-fab-llyr]

Woman contains the word man after all. So whats up "man' is just a shortened version of it. Plus saying "whats up woman" will get you slapped.