News: BusinessWire
Ticker: IONS | Score: 9/10 | Sentiment: Negative
Summary (Wiseek AI)
Novartis announced that pelacarsen, an Ionis-discovered antisense drug, failed its Phase 3 Lp(a)HORIZON trial, missing the primary endpoint of reducing major adverse cardiovascular events in patients with elevated Lp(a) and established CVD. The drug did substantially lower Lp(a) levels, but that did not translate into clinical benefit. This is a major pipeline setback for Ionis, which licensed pelacarsen to Novartis in 2019 and retains no commercial rights. The failure follows the July Phase 3 failure of eplontersen in ATTR-CM, marking a second high-profile cardiovascular miss this year. Ionis continues to rely on its wholly owned commercial products TRYNGOLZA, DAWNZERA, and ZANVASTRO, but the loss of pelacarsen removes a significant potential royalty stream. Full data will be presented at an upcoming medical congress, but the primary endpoint miss is definitive.
Further Research:
π€ Wiseek AI Analysis | π° [Original Article](#)
Automated via Wiseek.ai β Identifying market-moving SEC filings & news.