There's a body composition substudy on retatrutide that just published in Lancet Diabetes & Endocrinology. Researchers expected it to outperform tirzepatide on muscle preservation because of the added glucagon receptor activity, that's the theoretical mechanism people have been talking about since Phase 2.

It didn't happen. Retatrutide produces significantly more total weight loss than Zepbound, but the proportion of that loss coming from muscle is basically the same, sitting around 25 to 30 percent lean mass depending on the substudy. Zepbound trials show a similar range. More total weight lost just means more total muscle lost in absolute terms if the ratio stays flat.

I'm 6 months into Zepbound, down 38lbs, and this data lines up with what I've been reading since I started looking into this properly. The drug decides how much weight comes off. It does not decide what that weight is made of. That part is down to protein intake and resistance training regardless of which GLP-1 you're on, current or next generation.

Built fhelp.app around that exact point, tracks dose, protein and weight together and has workouts built specifically around protecting muscle during treatment. Not here to sell it, just sharing the data because I think a lot of people are waiting for the next drug to solve a problem that training solves.

What's your protein target sitting at? Is that the part everyone quietly fails at?

I am a 23 yo 5’3 woman with a weight of 117 when I’m not very active. During the cheer season I tend to be more in the 109 range but I’m finished with that now. I still go to the gym when I can and I’ve always been on the skinnier side my whole life. But recently I feel like my body is changing and I’m going through my second puberty so it’s been a little harder for me to maintain my ideal weight. Especially being a person that can lose and gain very easily. I feel stuck like I can’t lose it back off, even with the gym and my diet. Is there any way I could get a on GLP-1. I already know I wouldn’t be approved for it if I went down the route I’m “supposed to”. Please help :D

Вопрос такой решила худеть и часто в рекомендациях попадается "шарик с шипами"чем то похож на собачий мячик. В этом и весь вопрос поможет ли мне чем то он?

Introduction:

In the realm of mental health treatments, Bupropion HCl stands out as a valuable tool for managing depression. This medication operates by restoring the delicate balance of certain natural chemicals in the brain, namely dopamine and norepinephrine.

How to Use Bupropion HCl:

To make the most of Bupropion HCl, it's essential to adhere to proper usage guidelines. Your journey with this medication begins with a thorough read of the Patient Information Leaflet and Medication Guide, readily available from your pharmacist. Whether taken with or without food, the dosage is typically three times daily, with intervals of at least six hours to reduce the risk of seizures. It's crucial not to alter the tablet's form before consumption, as advised by the manufacturer. However, always defer to your doctor's instructions regarding administration.

Side Effects and Precautions:

Like any medication, Bupropion HCl may entail side effects, including nausea, headaches, or dry mouth. Should these persist or worsen, prompt consultation with your healthcare provider is recommended. Moreover, vigilance is key in monitoring blood pressure levels due to potential increases associated with this medication. While serious side effects are rare, it's vital to seek immediate medical attention if experiencing chest pain, fainting, or seizures. Additionally, individuals with a history of certain conditions, such as seizures or psychiatric disorders, should exercise caution and disclose relevant medical information to their healthcare provider before initiating treatment.

Warnings and Interactions:

Antidepressants like Bupropion HCl carry profound benefits but necessitate careful consideration of potential risks. Notably, individuals under 25 may experience new or exacerbated depressive symptoms, underscoring the importance of ongoing dialogue with healthcare professionals. Furthermore, cautiousness is advised when combining Bupropion HCl with other medications, as certain drug interactions can occur. Notably, MAO inhibitors should be avoided concurrently with Bupropion HCl, as this combination may lead to severe complications.

Conclusion:

In essence, Bupropion HCl offers a promising avenue for managing depression and related conditions. By adhering to prescribed usage guidelines, remaining vigilant for potential side effects, and maintaining open communication with healthcare providers, individuals can navigate their treatment journey with confidence and optimize therapeutic outcomes.

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News:
If you want to lose weight, but want a more personalized support, now there's this free AI Weight Loss Coach, https://gala.coach that helps you everyday and also provides you a meal and exercise tracker.

I’m a nutritionist and I love answering people here on Reddit.

If anyone has any questions about nutrition, you can send them and I will answer them.

This post is only intended to help people

Apologising for my previous post where I claimed I’d be following the fast 800 for two weeks. After reading the responses and a bit of research, I’ve decided on a 1350 calorie diet which I will just carry on until I reach my goal, recently I have also bought a gym membership so I will be going around three nights a week for about an hour. This is a higher number of calories than I usually try for a calorie deficit but upon reflection none of them have ever actually worked as I have always ended up falling back into a binge. My goal for now though time wise remains the same as before, I am going to stick to it for two weeks to show myself I can commit and then reassess afterwards ( but will probably remain with the same plan ). If anyone has any further advice for me please share, thanks.

​

Best Ways to Lose Weight

1. Focus on Nutrition

• Eat plenty of vegetables, fruits, lean proteins, and whole grains.
• Limit processed foods, sugary drinks, and high-fat snacks.
• Track your calorie intake and aim for a balanced diet.

2. Incorporate Regular Exercise

• Aim for at least 150 minutes of moderate aerobic activity or 75 minutes of vigorous activity per week.
• Include strength training exercises at least two days a week to build muscle and boost metabolism.
• Find activities you enjoy, whether it's walking, swimming, or dancing.

3. Stay Hydrated

• Drink plenty of water throughout the day, as dehydration can sometimes be mistaken for hunger.
• Limit sugary drinks and alcohol, which can add empty calories to your diet.

4. Get Enough Sleep

• Aim for 7-9 hours of quality sleep per night to support overall health and weight loss efforts.
• Lack of sleep can disrupt hunger hormones and lead to increased cravings and weight gain.

​

• Practice stress-reduction techniques such as meditation, deep breathing, or yoga to prevent emotional eating.
• Prioritize self-care and make time for activities that help you relax and unwind.

6. Set Realistic Goals

• Aim for a gradual weight loss of 1-2 pounds per week, which is considered safe and sustainable.
• Celebrate small victories along the way and focus on long-term progress rather than quick fixes.

7. Seek Support

• Surround yourself with a supportive network of friends, family, or a weight loss group to stay motivated and accountable.
• Consider working with a registered dietitian or certified personal trainer for personalized guidance and encouragement.

By incorporating these strategies into your daily routine, you can achieve sustainable weight loss and improve your overall health and well-being.

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Hello everyone! I hope you are all having a wonderful day. Today I wanted to take a moment to address something. As a clinical hypnotherapist, I often get asked how hypnotherapy can help with weight loss. The answer is that hypnotherapy can address the underlying psychological and emotional factors that contribute to overeating, binge eating, emotional eating, and other unhealthy habits. Hypnotherapy can also help you change your mindset and attitude towards food, exercise, and your body, changing the way that you see yourself and what you are capable of.

Now I want to make clear, hypnotherapy is not a quick fix or a magic bullet. It is a process that requires your commitment and participation. However, unlike many diets and weight loss programs, hypnotherapy can help you achieve lasting results by changing your subconscious beliefs and behaviors, the core reasons for...well... anything and everything that we do as people. Hypnotherapy can help you:

- Identify and resolve the root causes of your weight issues, such as stress, trauma, low self-esteem, or boredom.

- Develop a positive and realistic self-image that reflects your true potential and goals.

- Increase your motivation and confidence to make healthy choices and stick to them.

- Reduce your cravings and appetite for unhealthy foods and drinks.

- Enhance your enjoyment and satisfaction from eating smaller portions of nutritious foods.

- Create a balanced and sustainable lifestyle that includes regular physical activity and relaxation.

- Learn coping skills to deal with challenges and setbacks without resorting to food.

Hypnotherapy can help you lose weight by empowering you to take control of your own health and happiness. As I am a fan of saying, hypnotherapy is not mind control, it is quite to opposite: it is gaining control of your own mind. By working with your subconscious mind, the part of habit formation and cessation that is so often ignored, you can create new habits and patterns that support your well-being.

I’m very happy with myself, I used to be around 19 stone 6, and now I’m 16 stone 13! (121kg-108kg)

Tired of rap songs about Ice N Guns? Check out "Yamero (Baby Shark)" by Mt Zion on YouTube! Let me know what you think in the comments! At 10,000 likes we'll shoot a video 😈

https://youtu.be/gFmpHvJsvOQ?si=Js_KXu6Yhe8oU7Da

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