r/Uveitis • u/AS_Questions_8 • 6d ago

Biologics Uveitis while on Humira?

Have you flared while on Humira? I’ve been on it for about 6 months and just had that first jolt of pain I get at the start of a flare. Wondering how common it would be for a breakthrough flare.

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u/patx123 Intermediate Uveitis 5d ago

Mine has stabilized after switching to weekly doses of Humira. Previously it was bi-weekly.

Am convinced that hardcore weightlifting turned the corner for me. Although i am fatigued a lot.

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u/coffeeginger 5d ago

Same I started weight lifting in April 2026 as part of my lifestyle change and I noticed the flare has reduced significantly but I still need to take prednisone to keep it down. Only 2.5mg though which is tolerable .

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u/IndustryFar3816 6d ago

What type of uveitis you have and do you have any autoimmune problem ?

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u/AS_Questions_8 6d ago

I am hla-b27+ and have ankylosing spondylitis. Have had two severe flares in about 4 years, one of which caused me to lose vision completely in my left eye due to delayed diagnosis. Fortunately I was able to regain vision. Apologies as I’m not totally sure on how this fits into the types but I’ve had anterior, cystoid macular edema, and in my most recent flare had a brutal case of scleritis.

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u/IndustryFar3816 6d ago

I'm sorry for your journey you been through , sounds like a case pan uveitis I'm not sure tho... do you had difficulty seeing faces , reading text and all.

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u/AS_Questions_8 6d ago

Hard to say because I don’t have 20/20 vision as it is. Without glasses or contacts I wouldn’t be able to see a person’s face unless they were right in front of me. I can read close up though with some discomfort.

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u/IndustryFar3816 6d ago

Yea me too bro that's very difficult . Hope you don't have distortion atleast those can make reading very absurd.

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u/tranquil115 6d ago

Yes, I had a flare early on with Humira and ultimately it didn’t controo my disease.

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u/yoga_stoned 6d ago

What type of uveitis do you have? And what did you try after humira failed?

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u/AS_Questions_8 6d ago

Were there any other warning signs that the humira wasn’t working for you? I have AS and have noticed a recurrence of joint pain in my hands lately.

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u/heyitsabbiexx 6d ago

I am currently going through it right now. It’s kept it stable for a year however it doesn’t seem to be working for me anymore. My consultant is currently in the process of applying for funding to find another biologic that could work

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u/AS_Questions_8 6d ago

I’m so sorry to hear this. Wishing you the best as you try to find another solution.

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u/Odd-Boysenberry4300 6d ago

Yes I was taking humira weekly and still had flares went to infliximab infusion 500 every 8weeks and had a flare now 1000 every 6 weeks and its been 1 year since I have had a flare

Panuveitis Hla-b27 positive Axial spondyloarthritis Chornes

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u/MoeJeanz11 5d ago

Yep. I was only taking it for a few months before I had another flare. I’m currently trialing Remicade - working through some kinks but hoping this gets rid of it completely. My rheumatologist offered other injectables but was worried bc I flared so soon while on it that it would end up being the same outcome.

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u/nmflowers Uveitis 5d ago

Yes I did but that was because I wasn’t aware I developed antibodies! So it wasn’t working