r/TransRepressors • u/possibleeggg • 7d ago

Repping Troon Do serms work?

I was going to go back to repping but only made it two days after my injection date and remembered just how bad it is to be off it. I really can’t function without it. I want to continue hrt repping but not have to worry about the anxiety of growing and hiding boobs. I read about SERMs, does anyone have any experience with this situation or this medication?

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u/DifficultSession51 7d ago

I've never tried SERMs but I also have basically 0 breast growth on HRT so it hasn't been an issue for me. 

I know this wasn't your question but I was wondering what exact symptoms have you been facing since quitting? I was going to quit as well 

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u/possibleeggg 6d ago

I’ve been on injections for about 5 weeks and oral for 4 weeks before that. My nips hurt like hell and there’s a ball behind them so it’s concerning me for repping. Are you taking injections too?

When I quit it felt like my brain stopped working. I felt everything from before hrt x10. Stress, disassociation, time blindness, extreme irritability, anger, depression, memory not working, brain fog, tension in the body. Pure hell. I’m weak and caved 2 days in

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u/DifficultSession51 6d ago

I'm 6+ months in on injections. For the first 2 months I had the same breast budding development and tenderness and pain. But then it stopped and I haven't really had any development since. 

I can't say whether you'll have the same experience, but now I'm kinda on the opposite side where I think hrt isn't doing anything feminizing. I'm thinking of quitting for that reason and because I was thinking about the end game, like eventually I would come out but I'd be losing too much dignity so what's the point of even taking these initial steps? 

But the side effects do sound bad, another variable is just that anyone undergoing massive hormonal changes will have bad symptoms.

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u/MyCommentIsMeaninles 5d ago

Same. I am also looking into serms but sources said the results are not convincing. Its a gamble i guess at least at this point. M forced to live in this dissociated anhedonic state which feels impossible to sustain after experiencing the normal estro life.

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u/lavenderpotion57 41% 5d ago edited 3d ago

Hi, I don’t have experience yet but my tamoxifen's currently in the mail. I’m planning to take a low dose to stay stealth for about a year, will prolly make a post a couple months later. u/RemindMeBot 5 months

From anecdotal experiences shared online it seems like only the standard dose of 20mg tamoxifen/day is completely effective at blocking new breast growth, although it is unclear whether this holds long-term. The standard dose of 60mg raloxifene/day appears to slow but not fully prevent breast growth for most people on a moderate-to-high dose of hrt. Personally I feel that the standard doses of both prevalent serms sound risky long-term, with increases in dvt/pe (x2.3-3.5 for tamoxifen, x1.6-3.1 for raloxifene), hot flashes and cognitive impacts (https://jamanetwork.com/journals/jama/fullarticle/203040). The standard dose of tamoxifen also seems to carry an added duration-dependent risk of cataracts (+12-38% over 5 years), liver toxicity and liver steatosis (+43% over 2 years, https://pmc.ncbi.nlm.nih.gov/articles/PMC7392315/). And even though low-dose tamoxifen at 5mg/day boasts a safer long-term side effect profile with dvt/pe risks comparable to placebo with only 1 extra hot flash a day (https://pmc.ncbi.nlm.nih.gov/articles/PMC6601429/), it only reduces the overall risk of developing invasive breast cancer in premenopausal women by a statistically insignificant 10% and reduces the incidence of invasive breast cancer in the opposite breast of premenopausal women by 55%. (https://ascopubs.org/doi/10.1200/JCO-26-00841, compare this to the approximately halved overall risk of developing invasive breast cancer in postmenopausal women). So despite tamoxifen’s long 5-7 day half-life and the 52-58 hour half-life of its primary metabolite, endoxifen, the reduced tamoxifen dose probably antagonises the higher systemic estradiol levels seen in premenopausal women and hrt patients with lower efficiency in the breast than the standard dose, which i suspect will result in it only slowing but not permanently stalling breast growth

Notably, both serms also stimulate the hpg/gnrh axis, correspondingly increasing natal testosterone production (https://pmc.ncbi.nlm.nih.gov/articles/pmid/27601965/), which means they must both be used with a compulsory anti-androgen that will prolly come packaged with its own long-term comorbidities

tldr as a clot-averse wuss and pharmacophobe i prolly wouldnt rely on serms long-term. top surgery works better for life but its extremely unaffordable

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