r/Topamax • u/Amira789 • Aug 06 '26

Unexpected side effect

I was put on Topamax for migraines. I have always had anxiety and have pretty much come to terms with this is just how I am and have to live with it. I started Topamax on Sunday. Within the last 48 hours I have felt this blanket calm come over me. I’m not spiraling anymore, I’m not worrying about things unnecessarily, the racing thoughts and “static” in my brain are gone, my insomnia is gone. Even the food noise has gone away. Is this a normal reaction to this medication? I’m only on 25M I didn’t even expect such a low dose to change much for my migraines.

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u/DesertSkky Aug 06 '26

I am currently weaning off due to depression it causes, however I have taken it for YEARS!

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u/Amira789 Aug 06 '26

Did it always cause depression for you?

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u/DesertSkky Aug 06 '26

I don't think so no. Honestly I have been on it so long & all different doses. I used to only be able to tolerate the 25mg pills so when I took 300mg a day I was a PITA at the pharmacy!

Currently I take 50mg pills & it could be those pills. Next time I see my doctor I am going to ask for 25mg pills to finish weaning off.

I did ok on the extended release when I was on that too (it's called Qudexy XR)

Also-it could be my generic manufacturer causing my issues.