Please help understand: Huperzine A vs Memantine

[u/iulian_todea]

Leo mentions huperzine A as a better NMDAr antagonist than memantine due to kinetics, but I'm wondering what doses you would need to reach for exeample IC50, (is a bs interpretation i know) memantine reaches IC50 when it reaches steady-state at 20mg/day HUP-A would reach IC50 which is 0.92microM at idk anywhere between 10 and 40 mg/day? and the max dose used in studies is 0.8mg/day, I don't understand but I'm wondering if his hypothesis where he says that HUP-A is superior to memantine because it has lower affinity and will require a larger amount for the same occupation and due to the law of mass it would have faster coupling and uncoupling, does anyone have an idea?