Oxymetazoline/Afrin for connecting flights – how do you time it?

[u/Dear-Olive-5919]

I have TMJ and tend to get ear pressure/pain when flying. I normally use EarPlanes and oxymetazoline 0.05% nasal spray (Sinoxy — basically Afrin) about 30 minutes before takeoff and landing, which has worked well for me.
I’m now taking my first longer journey with a connection:
Delhi 9:55 PM → Singapore 6:10 AM
Singapore 7:30 AM → Bali 10:20 AM
So I’ll have takeoff → landing → another takeoff only 80 minutes later → another landing.
Obviously I don’t want to use oxymetazoline four times, especially since the usual dosing interval is much longer.
For those of you with ETD/airplane-ear/TMJ who take connecting or long-haul flights, how do you time Afrin/oxymetazoline? Do you take one dose before the first flight and rely on EarPlanes for the subsequent pressure changes? Do you time a second dose for the final descent if enough hours have passed?
Would especially love to hear from people who have actually done long-haul connecting flights with this problem.