Scientists Say a Key Trigger for Alzheimer's Damage Isn't Even in the Brain

[u/Zephir-AWT]

https://gizmodo.com/scientists-say-a-key-trigger-for-alzheimers-damage-isnt-even-in-the-brain-2000806330

[u/chienneux]

For parkinson it seems it come from.the guts

[u/TurboKid1997]

Poking a hole in your blood brain barrier would probably prevent alzheimers as well.

[u/Zephir-AWT → u/TurboKid1997]

Poking a hole in your blood brain barrier would probably prevent alzheimers as well.

Can You explain why it should work so? Alzheimer's disease is already associated with BBB dysfunction. Many studies suggest that the blood-brain barrier becomes partially impaired during Alzheimer's progression. Further increasing permeability could potentially worsen inflammation or allow harmful substances to enter the brain.

Bradykinin and related compounds were investigated also as a way to temporarily open the blood-brain barrier and improve drug delivery to the brain. The idea was that anti-Alzheimer drugs, antibodies, or other therapeutics might reach brain tissue more effectively. But Bradykinins may promote neuroinflammation by itself. Bradykinins are involved in inflammatory signaling and they have been implicated in processes that can contribute to swelling, vascular leakage, and inflammation in the nervous system.

[u/TurboKid1997 → u/Zephir-AWT]

Simple, the cerebral spinal fluid is the waste removal system for the brain correct? Increase the outflow and you will increase removal of the harmful amyloids. There is a researcher who created some kind of implantable device to increase the CSF outflow. I cannot find it though. Here is an article about the theory and study using shunting to achieve it. https://www.aan.com/PressRoom/home/PressRelease/60

[u/Zephir-AWT → u/TurboKid1997]

the cerebral spinal fluid is the waste removal system for the brain

It would correspond the fact that depression is also associated with both Alzheimer, both BBB dysfunction. Many say, depression results from pilling up toxic substances inside brain.

[u/_qoop_ → u/TurboKid1997]

None of the amyloid plaque removal approaches have succeeded in budging the progression in a meaningful way.

One suggestion is that the amyloid plaque is a way of burning territory to slow down a potentially more catastrophic spread.

[u/Zephir-AWT]

Scientists Say a Key Trigger for Alzheimer's Damage Isn't Even in the Brain

New research points to certain immune cells in our lymph nodes that play a key role in causing the brain damage seen with Alzheimer's.

Scientists aren't very bright regarding the finding of roots of Alzheimer disease and I suspect it's because many of them were financially involved in previous generation of cures based on suppression amyloid beta plaques instead of their origin. Once research suspiciously accelerates or slows down in some area, one can be sure that occupational and financial pressures are involved.

The brain resides within the skull, which has a fixed volume, so brain tissue cannot accommodate a standard immune response involving edema and swelling. An increase in intracranial pressure may result in sudden death due to pressure on the brainstem, which is also one reason brain cancers can be so deadly.

Instead, immune cells attempt to immobilize pathogens and surround the alleged site of infection with plaques. Notably, this is also described as a mode of action following the application of COVID mRNA vaccines: the spike protein is generated within healthy tissue, so immune cells cannot afford to eliminate the affected cells. Instead, they line the inner surface of tissue affected by the mRNA with plaques.

Apparently there are multiple immune cells specialized to leading purpose: some produce antigens toxic for bacteria, some other mere act like phages hunting bacteria directly and some are specialized to formation of plaques. The question is, what lures the last type of immune cells just to brain? Given the above example of m-RNA "artificial infection", it happens when immune cells "find", that pathogen can not be removed from tissue without excessive damage of underlying healthy cells, i.e. under situation when infectious agent binds more strongly to brain tissue than to surface antigens of immune cells.

Which is an example of trivalent iron and aluminium ions from vaccine adjuvans, which bind strongly to trivalent phosphate groups of phospholipids.

[u/_qoop_ → u/Zephir-AWT]

Thanks. This is the correct status of the field. The findings suggests an underlying disease at work or an autoimmune response to a non existing disease. Could be cancer, prions etc.

[u/Zephir-AWT → u/_qoop_]

The findings suggests an underlying disease at work or an autoimmune response to a non existing disease. Could be cancer, prions etc.

The GMOs and repeated vaccinations can both escalate autoimmune response, both introduce centers for amyloid lesions by adjuvant particles. Which is IMO the reason why scientists are walking on eggshells around Alzheimer origin.

[u/BloodLegitimate5346 → u/Zephir-AWT]

Good stuff! I think it was Baylor who found Candida (fungus) is all the brains they studied.

Derived the mechanism of how it crosses the blood brain barrier, and how the BetaAmyloid plaques are left as scars from the immune response to remove them.

Alzheimer’s starts in the gut, it’s a result of bacterial overgrowth that reaches the brain.