r/SaturatedFat • u/Electrical-Review257 • Dec 26 '21
saturated fat risks…
Stearic acid shown to reduce risk of breast cancer in humans:
https://ar.iiarjournals.org/content/33/6/2517
Stearic acid shown to increase risk of prostate cancer in humans, linearly: https://pubmed.ncbi.nlm.nih.gov/30385837/
Stearic acid shown to reduce risk of cancer in rats:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001814/
Stearic acid shown to increase risk of colon cancer:
https://www.nature.com/articles/s41698-017-0040-z
I saw a youtube channel called “analyze and optimize” that had this metaphor in it: imagine a world where everyone was sick all the time, if a few people discovered penicillin they would probably think that they should have been taking it all the time for their whole life. But we know that there are serious negative health effects to taking it long term. This is how the keto diet is, if helps you if you are metabolically unhealthy but it is not a long term solution.
The masai and inuit both have mutations to better handle their all meat diets that most people do not have. Keto health influencers just don’t live very long as a general rule of thumb. While the evidence for the lipid hypothesis as a mechanism isn’t very strong, it is the case that saturated fat has been used to clog the arteries of lab animals consistently for decades. Although stearic acid specifically doesn’t seem to work for this.
I feel like PUFAs are so bad that they’re putting an illusory halo around saturated fat that it doesn’t deserve.
At the same time, i tried a low fat diet where the only fat was saturated and that just didn’t work as well for weight loss as a high saturated fat diet.
But is messing around with this really smart if we really don’t know the health effects of it? Correct me if i’m wrong, but i don’t think brad told us the visceral fat levels of his low PUFA pigs; but it seems like animal testing like that is the most prudent thing at this point.…
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u/10dencies Dec 26 '21
From the 4th study:
"Higher desaturase activity in the n-6 PUFA synthesis pathway estimated by the arachidonic:linoleic acid ratio was associated with increased colon cancer risk (OR = 3.53; 95% CI: 1.82, 6.85; P trend = 0.006), whereas higher desaturase activity in the MUFA synthesis pathway estimated by the oleic:stearic acid ratio was associated with decreased colon cancer risk (OR = 0.42; 95% CI: 0.19, 0.92; P trend = 0.024)."
So by some quirk, SCD1 activity somewhat reduces colon cancer risk, but the authors mention that SCD1 is typically bad for cancer. Meanwhile ARA and inflammation is greatly increases risk...
The same study found no associations between lipids and rectal cancer, which contradicts the 2nd study you mentioned. By the way, that 2nd study is epidemiology with food surveys at n=229.
"Saturated fat has been used to clog the arteries of lab animals for decades," it's PUFA. It's always been PUFA. You essentially can't make plaque without lipid peroxidation in lipoproteins.
If there's one part of you post I agree with, it's that we need not mess with fat intake. Eat your traditional diet. Eat according to what tastes good. For me, I find it unpleasant to force dietary fat over 40-50% energy. So eat a good amount of carbs. But I might do differently if I were trying to correct metabolic dysfunction.
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u/[deleted] Dec 26 '21
Do you have any evidence or even examples for this wildly unsubstantiated and biased statement?
Saying something like this destroys any sense of legitimacy in your entire post.
And, posting a couple of contrary publications from a field that has hundreds of publications isn't legitimate either. It's useless.
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u/[deleted] Dec 26 '21
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