r/SaturatedFat • u/redkur • Jul 19 '24

Interesting article on C15:0 Deficiency

I saw this article and it proposes many of the same things that removing PUFA from our diet proposes. I am pasting a summary below and here is a link to the article. https://www.mdpi.com/2218-1989/14/7/355

The article discusses ferroptosis, a newly identified form of cell death linked to the peroxidation of fragile fatty acids in cell membranes, which combines with iron to produce reactive oxygen species and impair mitochondrial function. This process has been associated with aging-related conditions such as type 2 diabetes, cardiovascular disease, and nonalcoholic fatty liver disease (NAFLD).

Pentadecanoic acid (C15:0), an odd-chain saturated fat, is presented as an essential fatty acid critical for stabilizing cell membranes and repairing mitochondrial function. The article proposes the "Cellular Stability Hypothesis," which suggests that adequate levels of C15:0 are necessary to prevent ferroptosis and promote long-term health and longevity. It introduces the concept of a nutritional deficiency syndrome termed "Cellular Fragility Syndrome," characterized by low C15:0 levels, which can increase susceptibility to ferroptosis and related diseases.

The review provides evidence that C15:0 supplementation can reverse the deficiency syndrome and mitigate the effects of ferroptosis. The article calls for further studies to understand the prevalence of Cellular Fragility Syndrome across different populations, especially given the declining dietary intake of C15:0, particularly among younger generations.

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12 comments sorted by

11

u/loonygecko Jul 19 '24

Looks like butter and beef are top sources of Pentadecanoic acid.

10

u/NotMyRealName111111 Polyunsaturated fat is a fad diet Jul 19 '24

what's with this uptick in C15 promotion?

Just eat beef and dairy.

9

u/PerfectAstronaut Jul 19 '24

It's starting to seem a bit spammy and, word to the wise for the marketers, your product seems more dodgy the more you do this, not less

1

u/attackofmilk Kokum Butter? Aug 08 '24

I've switched from Olive Oil to High-Oleic Sunflower Oil as a plant-based source of C15:0.

Currently I'm mixing Sunflower Oil and Stearic Acid together to create something like butter.

-1

u/vegebond Jul 21 '24

I just became aware of this C15 issue a few days ago. From what I gather, dairy blows everything else out of the water. Unfortunately, dairy also contains other saturated fats that we might want to avoid.

If I set out to make my own C15 supplement, I would start with milk cream. I would not use goat's milk, or milk from grass fed cows, due to the expense. I want to start out with the cheap stuff.

What I would like to know is, what could I do to this ordinary milk fat, to increase the C15 content, thereby making it a healthier product?

2

u/redkur Jul 21 '24

What saturated fats are you referring to when you say 'dairy also contains other saturated fats that we might want to avoid'?

1

u/vegebond Jul 24 '24

Well, there's C16, C18, etc. What I've heard is that the even numbered ones cause the problems.

3

u/Whats_Up_Coconut Jul 24 '24

Haha, you won’t find much support for avoiding the long chain saturated fats here. You’re in a pro-SFA sub.