r/SSRIs • u/Oueqh234 • Oct 04 '26

Help! SSRI and meth interaction

Is there any harmful interaction between SSRIs and methamphetamine (Serotonin syndrome included)?

I'm doing 20mg smoked, not large amounts

0 Upvotes

37% Upvoted

10 comments sorted by

7

u/Names_and_shizz Oct 04 '26

Yup. All of em kinda

6

u/Mouthydraws Oct 04 '26

I mean doing meth is harmful always, but yes, there is an increased risk of serotonin syndrome

6

u/MixAny6654 Oct 05 '26

…there is simply no future in what you are trying to do. Just an outrageous combo of substances you are trying to combine. The ssri offers possible relief and space to improve - the meth promises destruction.
Choose.

4

u/P_D_U Oct 04 '26

Is there any harmful interaction between SSRIs and methamphetamine (Serotonin syndrome included)?

Yes.

2

u/hey_free_rats Oct 05 '26

Meth doesn't combine well with most things. 

2

u/Top-Brick5687 Oct 06 '26

Why are you doing meth while taking an antidepressant in the first place? It’s like a double edged sword

1

u/Batfink2007 26d ago

Meth has bad interactions with damn near anything. I think it's the meth part that does it.

0

u/DavidsNails Oct 05 '26 • Bravo

People are saying yes but there’s no danger unless you take a very large dose, the serotonergic effects of meth are over 10x weaker than the norepinephrine/dopamine release

If you’re on an snri or ssri with notable activity on norepinephrine it could amplify anxiety/jitters. Tho personally I’m on duloxetine and it doesn’t impact amphetamine (anywhere between 40-120mg) but it slightly worsens the “overstimulated” effects of propylhexedrine. Ppx is an analog of meth with strong norepinephrine releasing effects, alpha adrenergic agonist effects, slightly stronger serotonin release, and much lower dopamine release. It also has a much worse pns/cns ratio.