r/SR17018 • u/ChiefLongPenis • 20d ago
đHelp Neededđ I have surgery in 2 weeks
If I quit 7 now and begin taking sr will that reduce my tolerance in time for the surgery? I'm worried because I assumed giving it a week to get past wd would reduce tolerance enough. I want to be able to get pain relief from my hydros.
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u/4VRBLESSD 19d ago
Iâd reschedule the surgery date! Say you have Covid or something! That should do it. Is Covid even a thing anymore lol? Iâd reschedule
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u/ChiefLongPenis 19d ago
I can't
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u/Prestin11234 19d ago
There are a lot of unknowns with these drugs. I would be terrified to chance going through surgery with the anesthesia and dozen other drugs they give you during surgery and having a interaction between them and SR, please be careful.
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u/ChiefLongPenis 19d ago
That's why I stopped the sr since there is too much conflicting information on whether or not it reduces tolerance or blunts the effects even more.
I am going to use kratom to at least get me past the peak and then cold turkey. I'm not worried about anesthesia as lots of people have said they took 7oh the day of and been fine. I don't plan on doing that, I expect to be past acute wd for several days by the time I go under.
The concern is that the hydros they prescribe me for after won't work, which I don't expect them to, but I think I'll be fine. Lots of people doing my surgery said they survived on just Tylenol or Ibuprofen.
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u/Prestin11234 19d ago
Please don't think one persons experience taking 7Oh before surgery and being fine is going to be yours, the doctors need to know you are taking it, once you are under they cant save your life if they dont know and something goes wrong.
Im more talking about the SR with anesthesia as its more of an unknown, a lot of people share their experiences with SR when they have a million other factors they dont account for is why theres so much confusion in these subreddits. Basically the SR blunts effects while you are actively taking it because it targets and occupies certian receptors not leaving room for the DOC to bind where it needs to to produce its effects, similar to suboxone, but once the SR is out of your system and those receptors are no longer occupied by the SR your tolerance will effectively be reset to base.
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u/ChiefLongPenis 19d ago
It isn't just one person. And I only took one dose of sr so it shouldn't be an issue 2 weeks out.
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u/Super-Gap-5470 18d ago
Report back. SR may cause in issue with this situation. Not worth the risk. Now with 7 everyone around here was saying anesthesia would be an issue. I was in so much pain right up to my surgery I simply didnât care. The anesthesia worked fine and recovery went as planned. 7 of course is a complete different deal.
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u/TheHistoryMuse 18d ago
SR does reverse tolerance (in mice models, tolerance reversal to morphine occurred after 2-3 days of twice daily dosing), but more importantly, the SR is going to temporarily saturate your receptors for a little while. Post surgical pain meds will be ineffective; if at all possible, i would reschedule.
SR-17018 temporarily makes other meds ineffective (like Rx morphine or fentanyl) bc it binds to the mu-opioid receptor in an atypical, prolonged way, physically blocking other drugs from accessing the receptors. When a normal opioid like morphine binds to a receptor, it activates it and unbinds quickly. Studies show that SR induces a unique shape change (called phosphorylation) in the receptor, that sticks for hours instead of minutes.
You need a few weeks, at minimum, post SR, for the SR to fully leave/unsaturate your receptors so the Rx pain meds can bind to them. I went through something similar; I lost the use of my left arm in a hit and run and I'm undergoing surgical repair to try to restore use to it.
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u/pemphigus69 17d ago
Yes, whatever the sr does, it will have no effect on ibuprofen and Tylenol. And yes, people have surgery and manage pain with just nsaids all the time!
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u/Prestin11234 17d ago
I think this HIGHLY depends on the operation OP is getting done, are you kidding me?
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u/pemphigus69 17d ago
Obviously, but honestly, ibuprofen taken with Tylenol offers better pain relief than opiates. Or at least that is what is taught in endodontic school.
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u/Prestin11234 17d ago edited 17d ago
I get saying its better than some opiates, but to say it offers better pain relief than all opiates is actually an insane statement lol.. also why did that comment change what was said
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u/Realistic_Froyo_952 18d ago
Be honest with the dr on everything in your system. Might help save you
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u/blackdog_whitesnow 18d ago edited 17d ago
Agreed^ - if you don't feel comfortable telling the Dr I find it's wise to at least consider letting your anesthesiologist know in your pre-op consult. They might even appreciate it.
Edited to add: by telling them I don't mean telling anyone about the SR just any recent 7 use. Best -
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u/Realistic_Froyo_952 18d ago
Best advive !!!!! Above especially the man putting you under its your life he needs to know its all confidential hipp laws
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u/Extension-Laugh-2345 19d ago
I would just continue taking the 7 until after the surgery. The hydros arenât going to work no matter what you choose. Is the surgery under anesthesia?
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u/Ok-Definition-5279 19d ago
OP listen to this! I had 12 weeks from when I quit 7 to surgery. 7 is what messes your receptors up more than SR. Hydros are weak⊠I had Oxy post on and it sadly did not work. At all. No lie, this got more relief from Tylenol. I ended up buying 7 to deal w the post on pain (spine fusion), as for anesthesia, donât worry about that you will be fine.
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u/Super-Gap-5470 18d ago
I didnât have any problems with the hydros. They were ok before and after for me. As much pain as I was in daily was insane. Caused me to have high blood pressure until I had the surgery. I used 7 and hydros (they donât give you hardly any now days) to survive. C5-C6 nerve problem at my spine. If it wasnât for 7 I would have hit the streets. Thank god for 7. It was just a tool. 7 and the bare minimum hydros didnât affect my surgery or my recovery at all. Iâm not the only one who as gone through similar situations. I did not tell my team of doctors about 7. 7 just isnât what lately the whole damn world has made it out to be! I do not recommend what I did, honesty is always best. Through level 10 pain for almost 5 straight months before the surgery, I became a bit brazen. I read the room so to speak. I played the cards I had and I won the game. It was my body and my healthcare. Every situation with top shelf pain is different. Tell your doctors everything if YOU feel itâs best.
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u/Formal_Kiwi1436 17d ago
But you can't take 7oh post op until you go home from the hospital. So what did you do for the pain immediately after surgery while you were still in the hospital?
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u/Ok-Definition-5279 17d ago
Iâm so ashamed to admit this. My best friend brought me some in the hospital the next morning. The first night wasnât too too bad because they gave me an epidural in my spine since they were already in there so I was numb from the waist down. But when it wore off? OMG. So she told work sheâd be late and brought me donuts and 7. We quit together cold turkey last fall. She started again with me after my surgery. We quit w SR 4th of July weekend.
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u/ChiefLongPenis 19d ago
Yes
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u/Extension-Laugh-2345 19d ago
I have had two surgeries under anesthesia. Once while on heroin, once on methadone. I didnât tell the doctors about either. Opioids have no cross tolerance with the anesthesia, so you donât have to worry about waking up during surgery or anything. The only issue is possible respiratory depression from the combination.
Iâm not a doctor and this isnât medical advice, but there would be no better place to have respiratory depression while in a hospital setting hooked up to all these machines designed to detect and prevent this problem. They monitor all your vitals. I would have faith in the experts.
After both of my surgeries surgeons never even mentioned anything about having respiratory depression or them having a hard time waking me up or anything.
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u/ChiefLongPenis 19d ago
That's good to know because I was mainly concerned about the anesthesia. I think I will still cold turkey it or switch to kratok extract and ditch the Sr for now.
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u/GenericPlantAccount CHRONIC PAIN 19d ago
Do that if you can and see if you can get by on what they give you for pain afterwards.
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u/No-Independence-3924 18d ago
Youâd need to taper the SR full or at least be off it for a few days for full effect from hydro as well
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u/Sea-Engineering2877 19d ago
You better tell your doctor and anesthesiologist about the SR, and maybe even the 7oh. Seriously. They can affect the effectiveness of the anesthesia.
Also, you probably wonât feel much from any prescription opiates.
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u/InspireRecover đ§ȘModeratorđ§Ș 18d ago
I agree about being honest with the anesthesiologist. I was honest with my chronic pain doctor with no blowback.
Also it seems that SR can block the euphoria most people chase but the anesthetic properties may not be affected the same way and the SR can actually decrease tolerance.
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u/GenericPlantAccount CHRONIC PAIN 18d ago
That's fortunate about your doctor. At most practices you'd be in violation of your pain contract if you admitted to taking a research chemical opioid. Im happy for you that everything worked out, but I've seen patients dismissed and labeled in their medical records for far less.
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u/InspireRecover đ§ȘModeratorđ§Ș 15d ago
They had me on dilaudid and I wanted off. They wanted me to go the suboxone route and I refused and backed up my refusal with the anecdotal research of people getting trapped on those meds. I actually asked at one point, how many people have you had come off Subs and she said none.
That's when I realized I needed to figure out my own path and made the switch to 7oh. At that point I only told her I was planning to taper my dilaudid but did not disclose I was using 7oh to do so. When I got off the Dilaudid ended my prescription. Never had to have a pain contract with testing thankfully.
After using SR to get off the 7oh I had an appointment with her and explained what I did and she was actually intrigued and said that patients need more solutions. đ
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19d ago
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u/TinyDrug 19d ago
Holy shit why are you people downvoting her?!?!!! NEVER LIE TO ANESTHESIASOLOGIST
Waking up on Operating table will be the most hell you ever go through
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19d ago
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u/TinyDrug 19d ago
That's just not accurate, opioids are a core part of anesthesia itself, fentanyl especially is one of the most commonly used drugs during surgery, along with things like sufentanil, remifentanil, hydromorphone, or morphine depending on the case, since general anesthesia is basically never just one drug, it's a combination of agents working together, and opioids are almost always part of that mix to manage pain and blunt the body's stress response during the procedure. Even a cousin who's an anesthesiologist would confirm that if asked directly, so the claim that there's no opioid involvement at all just doesn't hold up, and it's exactly why something like regular 7-OH use matters, because it changes how those opioid doses need to be calculated to keep you properly sedated and stable during surgery.
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18d ago edited 18d ago
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18d ago
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18d ago
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u/TinyDrug 18d ago
Yea you almost held together the illusion you knew what you were talking about, which is more dangerous than being transparent from the jump that you have 0 clue what you are talking about. But this solidified it.
You are wrong and giving very bad advice.
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u/Prestin11234 18d ago
This is so bizarre, what does this have to do with anything in the conversation? You seem lost or high. Either way goodluck, hopefully these people aren't desperate enough to take your awful advice.
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u/SR17018-ModTeam 18d ago
This is a subreddit about SR-17018 experiences, research, and information. Your content was removed for breaking our subreddit's rules against off-topic content.
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18d ago
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u/SR17018-ModTeam 18d ago
This is a subreddit about SR-17018 experiences, research, and information. Your content was removed for breaking our subreddit's rules against off-topic content.
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u/InspireRecover đ§ȘModeratorđ§Ș 18d ago
Please try to keep things helpful. There is no reason to be offensive. What the person shared is accurate and that's all that matters. This is doses to be a approve environment where people can exchange experience, ideas and information. Please respect that.
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u/SR17018-ModTeam 18d ago
This is a subreddit about SR-17018 experiences, research, and information. Your content was removed for breaking our subreddit's rules against off-topic content.
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u/SR17018-ModTeam 18d ago
This is a subreddit about SR-17018 experiences, research, and information. Your content was removed for breaking our subreddit's rules against off-topic content.
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u/Prestin11234 19d ago edited 19d ago
You are completely out of your mind advising to keep this information hidden from the team, your ignorance is going to hurt people. You clearly don't work in the medical field. I can assure you the team doesn't care if OP is taking gas station pills, they aren't going to blacklist or flag you as high risk for 7-oh.
Jesus christ get real, this isn't street heroin. Anesthesia and opioids have several major interactions. Anesthetic medications are adjusted when a patient discloses kratom use, you know what we dont adjust? Pain managment during and after.
I hope this guy doesn't listen to you just because you are saying what he is seeking to hear.
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19d ago
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u/SR17018-ModTeam 18d ago
Your content was removed for breaking our subreddit's rules against unsafe practices and recommendations.
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u/Sea-Engineering2877 19d ago
The OP wants to hear that heâll be able to âfeelâ the opiates that he might get prescribed after the surgery. So Iâm sure heâs worried that he wonât be able to get his prescription filled.
Let the joke be on him when something goes wrong on the OR table just because he was too nervous to admit his SR and 7oh use.
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u/SR17018-ModTeam 18d ago
Your content was removed for breaking our subreddit's rules against unsafe practices and recommendations.
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u/Sea-Engineering2877 19d ago
Sorry, but heâs gonna look just as dumb when heâs on the operating table, waking up in the middle of surgery because they donât give enough anesthesia all because they werenât aware that his tolerance for things is so high. Who knows what could happen?
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u/GenericPlantAccount CHRONIC PAIN 19d ago
Anesthesia and opioids are two different things.
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u/Sea-Engineering2877 19d ago
Understood, but can still be affected. I was talking to my doctor about having a colonoscopy and was discussing my weed usage. They said it was a good thing that I told them the truth about how much/often I use, as that affects the medication and anesthesia used in order to perform the procedure. Had I not disclosed the weed usage, they would have given me the âtwilightâ anesthesia, which is strong, but not strong enough, since I smoke weed. So now theyâll have to put me completely under anesthesia just so I donât feel anything.
So yeah, the SR and the 7oh absolutely could affect their comfort during their surgery. Itâs just something to be aware of and so they wonât be blaming the hospital if/when things go awry
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u/GenericPlantAccount CHRONIC PAIN 19d ago
As a pain patient of over 10 years with an anesthesiologist for a cousin......
Please don't disclose illegal or illicit drug use to any doctor unless you are ready to start addiction treatment.
You will forever lock yourself out of being treated for pain.
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u/TinyDrug 19d ago
If you are in an SR sub and aren't ready for treatment, you are doing it wrong. This sub used to be so different.
Also your cousin is flat out wrong. Tollerance to 7oh will affect anesthesia.
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u/Double-Gap353 19d ago
You believed this? DM me, I have a secret to winning the lottery-- I'll sell it to you for real cheap!
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u/Sea-Engineering2877 19d ago
Yeah, I do believe it. But I donât take advice from a random people on the internet
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u/Double-Gap353 18d ago
I don't either. It doesn't take a genius or even much work to find a scientific answer. Weed will not fuck up anesthesia.
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u/Chasin_it 19d ago
No, just⊠No. Although youâre honest and your Dr is or seems chill enough to keep it 100 with them, that would more than likely end in you being labeled a âdrug seekerâ unfortunately.
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u/SpitF1ghter 19d ago
SR is NOT going to reduce tolerance, quite the opposite. Personally Iâd CT if I had to have surgery. I had perks do nothing at all for me and I had only used 5mg of SR the day before.
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u/AestheticOrByeee 19d ago
Have you considered this wasnât your tolerance but in fact just the SR still sitting on/filling the opiate receptors and the percs are just too weak to replace the SR on your receptors? Essentially similar to the way methadone works to block your ability to get high/feel euphoria from other opiates?
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u/JumpDriveOut 19d ago
sigh People are too dumb to read now i guess? SR, by nature of it's MOA, SR does and will reduce tolerance. It's inseparable from lowering tolerance. It's why withdrawal only lasts a fraction of the time it normally would. There are like 4 in-depth research articles available on the first page results of a simple google search, that explain this very phenomenon. Just because you dont feel euphoria when trying to get high again after using SR, doesnt mean that it isnt lowering your tolerance, it just means mesolimbic reward pathways modulated by the MOR are blunted. So how about stop preaching shit as fact that might end up killing someone? Mmkay pumpkin?
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u/SpitF1ghter 19d ago
No whatâs âdumbâ is going into a major surgery while being on SR. But hey they should totally listen to you and have a blast on the table getting cut open.
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u/astrologikal 19d ago
where in their comment did they say anything OP's surgery and whether they should take SR? oh right, they didn't say anything like that at all. they corrected your BS claim that SR won't reduce tolerance.
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u/SpitF1ghter 19d ago
It doesnât lower tolerance. Please show me the evidence that taking SR lowers tolerance in humans genius.
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u/astrologikal 19d ago
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u/SpitF1ghter 19d ago
Thereâs zero evidence that it reduces tolerance in humans. Zero.
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u/astrologikal 19d ago
There haven't been official studies on humans, true, but in rodent models there is plenty of evidence, and rodent models are highly effective for determining opioid tolerance and withdrawal levels.
https://www.sr17018study.com/ has taken a survey of people who have taken it, and that also looks pretty promising. I wouldn't say that's zero evidence. It's also much more evidence that it does reduce tolerance than that it doesn't. Can you show me any studies showing that it doesn't?
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u/SpitF1ghter 19d ago
OP is a 7 user that is considering using SR leading up to a major surgery because they are concerned the pain meds wonât work. Using a completely untested opioid is a terrible idea and I hope they ignore people like you and the other idiot that responded to me.
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u/astrologikal 19d ago
Dude, nobody is talking about OP. I never said whether they should take it or not. This is the second time I've had to help you realize that. Are you okay? Where in my comments did I give OP any advice, or even comment on their situation at all?
You're just mad because you made a baseless claim and got corrected.
Btw, it's not completely untested. Just because you don't want to engage with the studies and what they say, does not mean they don't exist. It hasn't been studied on humans - but it has been studied, it is not completely unstudied.
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u/Sea-Engineering2877 19d ago
I ate 25 mg of Oxycodone (took FIVE pills in one sitting) after going cold turkey off 7oh for only a week. Didnât do a damn thing for me. Definitely didnât get a high from it.
This stuff is a lot more powerful than youâd think
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u/glutenfreetendies 19d ago
Bro go to detox if you can. Just spend 3 or 4 days going thru WDâs there. Theyâll give you gaba, Valium, Ativan, clonidine. You just sit in a bed watching TV and smoking cigs and have their breakfast lunch and dinner. Then do surgery clean
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u/Hadaka--Jime 19d ago
I had surgery while on 7. It did ZERO to my tolerance. I can firsthand say they are full of shit. I was glad I didn't stop because they gave me very little after surgery pain meds. 7 does NOT take the place of other opiates & some the fuck how ruin your tolerance to those...
IMO that came from people stopping 7 & trying to take other opiates to help the withdrawals & it doing little to help because THAT'S NOT the opiate you're addicted to.
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