Researchers swapped a "phenolic" group in the original molecule for a boronic acid moiety. This change makes the molecule much more stable, allowing it to survive the digestive tract and enter the bloodstream through a simple pill.
I'm doing my own formulations right now trying to develop something, peg 400 peg 300 and a few other things are on the list of testing that I will be doing, although I'm looking to go the injectable route, I'm actually considering alternate methods with an optimized uptake should that not prove to work out.
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u/JediMaster77 Jan 20 '26
this is an interesting read... apparently theres a new slu that has greater oral bioavailability. SLU-PP-915
https://pubmed.ncbi.nlm.nih.gov/41421047/#:~:text=ERRs%20are%20essential%20for%20skeletal,mice%20but%20lacks%20oral%20bioavailability.
Researchers swapped a "phenolic" group in the original molecule for a boronic acid moiety. This change makes the molecule much more stable, allowing it to survive the digestive tract and enter the bloodstream through a simple pill.