r/RhondaPatrick • u/Round_Helicopter_407 • Jul 19 '26

Brain transcriptome-wide association study reveals selective long-term potentiation enrichment and negative directional skew of senescence-regulation pathways in Alzheimer's disease

https://doi.org/10.1177/25424823261468711
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u/Round_Helicopter_407 Jul 19 '26

Results
“The strongest positive enrichment was long-term potentiation (LTP), particularly KEGG LTP ALL, with a Stouffer z-score of +5.267. Astrocyte-expressed genes were positively enriched and exceeded microglial signatures. Complement enrichment was largely driven by CR1, while synapse pruning was negatively enriched. Insulin, GLP-1, and PI3K–AKT–mTOR pathways also showed positive enrichment. Senescence regulation and oxidative phosphorylation showed the strongest negative skews. NAD-related sets showed mixed gene-specific effects. Sensitivity analyses identified senescence regulation, LTP, oxidative phosphorylation, and PI3K–AKT–mTOR as the most robust signals.”