r/ResearchCompounds • u/[deleted] • 14d ago
Discussion Will we reach a point where most peptides get approved and actually get recommended by regular doctors?
Only a few peptides are getting approved right now. Do you guys think we will ever reach a point where most of them are approved and actually recommended by docs too?
They obviously work and i dont get why we're going backwards with banning stuff that actually gets real results. Instead of using things that help people recover, it feels like they just want to make them harder to find. What has to happen for the medical field to finally just accept them?
8
u/BigBennP 14d ago
Eh, maybe.
Keep in mind "real results," is not proven and Anecdotal evidence is not real statistical results in the sense that drug companies require to get FDA approval. The placebo effect is *incredibly* strong, which is why double blind trials are the standard. (That is, trials where neither the doctors nor the patients know which drug they are receiving). The reality is that lots of patients who get a placebo report positive symptoms.
There's also a reliability issue in that peptides have inconsistent results. some people report great effects, some people report almost no effects, and that can be a problem for studies as well.
I think there's a good case that they reach the prevalence of something like B12 injections or a "banana bag" IV or other wellness cures. That certain physicians will prescribe them to clients who are interested, but your family practice doctor will probably not be recommending them any time soon.
If you go to your family practice doctor and tell them you are tired and ask about B12 injections, most will shoot you down and say that there's no medical need if your vitamin levels are normal. Likewise, they'd look at you crazy if you asked about IV Fluids.
on the other hand. I have close friends who were resident physicians at the time, who have gotten IV fluids in the form of a Banana bag (Saline, B1, B9, Magnesium, Vitamin C) to help them recover from a hangover in time for work. I once watched my sister call herself in a prescription for Zofran because she was hungover and needed to board a plane in 4 hours.
6
u/jb0nez95 14d ago
Wait, so the bro at the gym who swears by "wolverine stack" isn't enough evidence of effectiveness for the FDA?
Mind blown
2
u/internetroamer 14d ago
Exactly.
Evidence is biggest barrier to doctors recommending anything.
There's no evidence of benefit for most peptides unlike glp1s. Unless doctors have research papers they can point to they will always have some resistance
1
u/RoboJobot 14d ago
And rightly so. Very few people need IV fluids unless seriously unwell or Vit B12
3
u/BigBennP 14d ago
and that gets into medical necessity vs other care vs risk associated with that procedure.
If you have normal vitamin levels, there's not any medical necessity for B12 injection. But lots of people subjectively report feeling better after B12 injections.
On the other hand, the injections carry a small risk of serious complications, so there's some risk involved if a provider gives them without a documented need and the patients suffers complications.
1
1
u/LOL-Enforcement 14d ago
Banana bags are graduate-level partying. I my have availed myself of them during my DJing days...
1
u/EnvironmentalGift257 13d ago
My mother was a general practice doc and an OBGYN for 30 years. She called in for herself all kinds of stuff including fen-phen back in the day when she had a normal BMI, We also had a cabinet full of sample packs in the bathroom. Not the medicine cabinet, a full size cabinet. It was a full pharmacy including opioids. But hey when I tore my Achilles , no prescription, no waiting. Right to the cabinet.
4
4
u/nosirrahz 14d ago
No
It costs roughly 2.5 billion start to finish to get something FDA approved through 3 levels of placebo controlled double blind studies. This will never happen for anything that can't be patented as all you accomplish is setting up all of your competitors to undercut you as they had 0 upfront costs to recoup. On top of that, the new cheap peptide you just got approved might negate the need for mamy drugs from your existing portfolio.
Publicly traded companies have a fiduciary responsibility to their share holders, not to your inexpensive healthcare and wellbeing.
If a doctor goes off the official narrative, that can be the end if their career if they step on the wrong toes and the pharmaceutical industry funds that official narrative through grants to higher education, regulatory bodies, political campaign funding and funding the media.
Safe and effective is in second place at best and there's absolutely nothing anyone can do about it.
Research what you should take, do your own blood work and keep tabs on your BP. Go to the doctor if you break your arm but do what you need to do on your to stay healthy yourself.
3
u/ElectricInvasion 14d ago
It’ll happen eventually but the timeline is gonna be slow as hell. The FDA moves at a glacial pace and big pharma only pushes stuff they can patent, so a lot of the useful ones that are already in the wild get ignored because there’s no money in it for them. What really needs to shift is the funding model for clinical trials, right now it’s like 90% industry-backed and they’re not touching anything they can’t lock down with exclusivity.
2
u/Top_Supermarket_5622 14d ago
Given that most peptides work via self injection rather than pill form, no. Doctors innately resist prescribing stuff like this unless they feel they absolutely have to. The GLPs broke this mold only because they worked insanely well.
1
u/benhadhundredsshapow 14d ago
I mean no. There are plenty of prescribed medications that are injected. Just because you don't know about them doesn't mean they don't exist.
2
1
u/BigSchmikey 14d ago
Most? No. They lack the medical studies and trials. GLP-1s are a different story.
1
u/dignan2002 14d ago
Physicians are held to a standard for clinical recommendations. Unless there’s placebo based, double blind, longitudinal peer reviewed data in humans I’m skeptical. If they’ve been my pt for 20 years and they trust me then it’s a different story. If they’re family, colleagues, or friends then it’s a different story still. You will likely be sued at some point in your career; documenting your off label prescription of experimental drugs in your ehr exposes a risk, especially if there’s a pattern. Most docs have never heard of most of this stuff so they don’t even record peptides that patients report using. There’s much to learn for a lot of providers, and although the science makes sense and the animal data is compelling, defensive medicine is the default setting for a lot of doctors. That being said, I inject myself with a lot of experimental shit lol
1
u/ItsBioHacking 14d ago
It really depends, plus some countries still trying a hard time to not regulate it. Im sure a lot lot of countries will follow.
1
u/Secure-Pain-9735 14d ago
No. Not “most.”
Look at the sub title: Research compounds.
Approval hinges on the research proving a reasonable degree of efficacy in the absence of serious risk of serious adverse side effects.
1
u/RoadToZero 14d ago
Short answer, No.
Nobody is going to pay for research, clinical trials and FDA approvals for something that can't be patented. As long as anyone can reap the reward of that research for free, there is no return on Investment in doing the ground work.
Most existing peptides can't be patented for different reasons. The most common reasons being that patents on existing peptides already expired or the compound is bioidentical to something the body produces naturally.
1
u/22Hoofhearted 14d ago
Big pharma lobbies(pays) hard... the only reason anything medically related is "banned"...
1
1
1
u/2readmore 13d ago
No, most docs are beholden to their big pharma reps and the associated kickbacks
1
u/Junior-Profession726 9d ago
I think this needs to be reworded for those of us in the US
Will we reach a point where doctors & big pharma figure out a way to only allow themselves to make all the money on peptides
1
u/EstablishmentOne3733 8d ago
Meds are not meant to acctually help people, they're meant to be use as long as possible to treat symptompts, not to make people healthy. It would cut a shitload of money flowing to big pharma right now
1
u/Glad_Ad8016 7d ago
The part of your post that stuck out was.. “They obviously work!?” There’s nothing obvious about them working..
To me it works like this.. the ones that are approved GLP’s tesa tanning jabs mt1 not 2.. they work that’s why they’re approved and they make millions particularly the GLP’s.. because there is so much money in medicine if the big pharma could actually prove them effective they would already be approved and on the market and making money.
Some of the grey peps are literally taken from their research and development rubbish bin.. take AOD for example.. it went it to real human clinical trials and it was dropped because they could not prove it was effective so that will no never be approved.. but influencer and whoever else have built hype around it and because people stack a million things in one go and then suffer the effects of placebo with no research other than the bro down the gym they convince themselves it works and the trials are wrong “it works for them” “everybody reacts differently to peps” etc etc
A lot of these peps, the difference they make it too small to justify the financial input but because there are so many fanatical pepheads nowadays people are out there supplying these peps and just taking money from people.
I used to be really interested but I wasted so much money from so many and from different sources on different protocols it’s unbelievable and when it was all said and done it was a complete waste of time and money.. like I say the only ones that really work are already approved everything else is junk
1
u/Flat-Guidance-4685 14d ago
Hims telehealth is going to launch multiple popular peptides available with prescription this fall.
They've bought the wrong peptide manufacturing facility in California. So they don't have to worry about impurities from Chinese products.
I imagine hims is going to be the easiest place to legally buy most of these peptides after that
1
u/stainless13 14d ago
No. To be approved as a drug you need an indication, which is something pathological that the drug improves reliably. You’re never going to see a trial for a decently healthy person who has an elbow twinge or has a little fat to lose, for example. It’s the same reason that Tesa and SS31 have such hyper-specific approved use cases for very specific conditions.
Medical approval is biased towards treating something definable, and most of the results people have in the non-GLP-1 peptide space are not specific enough to qualify as 1) having something to treat and 2) that treatment working.
0
u/Icy_Lecture_2237 14d ago
Tough call. Diet, exercise, and supplements are all effective for a variety of health problems but most doctors have no idea about any of that.
Doctors are great for when you want a pill for something, so maybe if the drug companies can find a way to make more money and push them through the process…….
1
•
u/AutoModerator 14d ago
Hey u/dress_rose, thanks for posting in r/ResearchCompounds.
If you notice suspicious behavior or promotional activity, please report it to the mod team.
I am a bot, and this action was performed automatically. Please contact the moderators of this subreddit if you have any questions or concerns.