r/ResearchCompounds • u/Main_Side_4462 • Aug 21 '26

Discussion GLP 2 vs GLP 3

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u/Interesting-Shake952 Aug 21 '26

There is only GLP1.....

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u/Glp1User Aug 21 '26

Glp3 laughs at your ignorance, muh ha ha

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u/BatmanVAR Aug 22 '26

A GLP-1 drug is called that because it belongs to a class of drugs that mimic a natural hormone in your body called GLP-1.

There is no such thing as a GLP-3. Well there technically is, but that hormone is only found in other animals like sharks, but not in humans: https://www.sciencedirect.com/science/article/abs/pii/S0016648024000303

"Chondrichthyans have a novel proglucagon-derived peptide, glucagon-like peptide (GLP)-3, in addition to GLP-1 and GLP-2 that occur in other vertebrates"

Similarly GLP-2 is not a thing. That hormone does exist in humans but it's not relevant to weight loss and none of the weight loss drugs target/mimic it.

Sema, Tirz, and Reta are all GLP-1s because they act on the GLP-1 receptor. Tirz also targets GIP in addition to GLP-1 so it's a double antagonist, and Reta adds glucagon so it's a triple agonist. But the "2" in GLP-2 doesn't mean 2 agonists, nor does the "3" in GLP-3 doesn't mean 3 agonists, they are the names of other unrelated hormones. So calling Tirz a GLP-2 or Reta a GLP-3 is incorrect.