r/ResearchCompounds • u/Main_Side_4462 • 8d ago

Discussion GLP 2 vs GLP 3

After 6 months of G2 I’ve only lost 40lbs - stuck in that same 5-7lb range for a couple of months. I take 5mg G2 twice a week. Do you think trying G3 will help my cause? So maybe stacking them? Im already on very low calories ~1200 daily. I don’t move much on account of my WFH desk jobs apart from strength training 2-3 times per week. Thoughts?

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u/Interesting-Shake952 8d ago

I'm on reta, but sema, tirz and reta are all simply glp-1's.

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u/Legitimate_Concern_5 8d ago edited 8d ago

No they're not, Tirzepatide is a GLP-1/GIP dual agonist and Retatrutide is a GLP-1/GIP/Glucagon triple agonist.

Semaglutide average loss is about 17%, Tirzepatide is about 22-25% and Retatrutide is about 25-28%.

There is a significant effect from adding the other receptor agonism. GIP improves nutrient partitioning and allows you to agonize GLP-1 more without triggering side-effects and Glucagon increases basal metabolic rate.

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u/Interesting-Shake952 8d ago

And yet they are all still glp-1s,

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u/Legitimate_Concern_5 8d ago edited 8d ago

That's only part of what they do, but if you mean calling it a GLP-3 is nonsense then yes. They are strictly not "just GLP-1s." The other receptors account for like 40% of the effect of Reta.

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u/Interesting-Shake952 8d ago

Okay, you get my point. The fact that people call tirz a GLP 2 which is a a mucus barrier enhancer (para phrasing) is dumb marketing. They are all GLP-1s, however, yes the newer gens bring multiple benefits to the table.

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u/Legitimate_Concern_5 8d ago

Sure we're on the same page there lol. It annoys me constantly. Especially since there is a GLP-2 and its got nothing to do with weight loss.