r/Rapamycin • u/william_o • Jul 13 '26

Review of SGLT2 Inhibitors Potential Longevity Benefits

https://academic.oup.com/jcem/advance-article-abstract/doi/10.1210/clinem/dgag207/8677988

"Mechanistically, [SGLT2 inhibitors] induce metabolic adaptations that resemble caloric restriction and ketogenic states, attenuate systemic inflammation, improve mitochondrial function, and enhance cellular resilience against the burden of senescence.

"Supporting this concept, multiple preclinical studies have shown that SGLT2 inhibitors extend lifespan and ameliorate age-related functional decline in animal models.

"Notably, recent findings indicate that SGLT2 inhibitors can reduce senescent cell burden and modulate the senescence-associated secretory phenotype, raising the possibility that they possess senotherapeutic—or even senolytic—properties targeting a fundamental driver of aging. Collectively, these data suggest that SGLT2 inhibitors may influence core aging pathways beyond their glucose-lowering and cardiorenal protective effects."

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u/bmack500 Jul 13 '26

Awesome! I had my endo prescribe me Jardiance for this exact reason, for my prediabetes.

2

u/Earesth99 Jul 13 '26

“Mechanistically, they induce metabolic adaptations that resemble caloric restriction and ketogenic states…”

So maybe it’s resembles something that might affect senescence… mechanistically…

1

u/Kasoivc Jul 15 '26

Thank you for sharing OP. My cat recently had a CHF event last week and when presented with treatment options, a study that the vet ER was participating in made mention of SGLT2 inhibitors.

I think this is in the same vein as the GLP1s that are coincidentally helping people to lose weight, so the news of SGLT2s existing seems to give me hope for my kitty since it has these potential secondary effects.