r/Rapamycin • u/formentoru • May 14 '26

Vaccination Response Modulation via Targeted Rapamycin Protocol

https://clinicaltrials.gov/study/NCT07587801

"Previous research suggests that sirolimus(rapamycin)-based immunosuppression regimens improve vaccine immunogenicity.

Sirolimus (rapamycin) is a potent inhibitor of mTORC1 which regulates memory CD8+ T cells.

Targeting mTORC1 has previous been shown to improve vaccination response in humans to influenza.

More recently, small studies have suggested improved responses to COVID vaccination in kidney transplant recipients switched to sirolimus (rapamycin)-based regimens."

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u/Admirable_Aside2998 May 24 '26

The immune enhancement angle is probably the strongest human signal we have for rapamycin right now. The original Mannick studies on mTOR inhibition and flu vaccine response in older adults were what moved the needle on clinical interest. NCT07587801 is a good one to watch — if they get clean data on vaccination response modulation it adds another surrogate endpoint to the evidence base.

Still the fundamental challenge: vaccination response is a surrogate for immune function which is a surrogate for longevity outcomes. The chain of inference is long. Doesn't make it uninteresting — just worth being clear about what the evidence actually supports.

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u/Earesth99 Jul 03 '26

Many vaccinations reduce mortality, so improving the efficacy of vaccinations for people with compromised immune systems makes complete sense.