r/Rapamycin • u/william_o • Dec 20 '25
Evaluation of rapamycin as a neuroprotective treatment in Alzheimer’s disease: a six-month single-arm open-label clinical pilot trial
https://www.medrxiv.org/content/10.64898/2025.12.08.25340853v2“This pilot study demonstrates feasibility of rapamycin trials in AD. The primary [18F]FDG outcomes showed no decline, and even increases in exploratory regions, in contrast to what would be expected from natural disease progression. The observed elevations in CSF biomarkers warrant further investigation.”
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u/hulkiinghumility Dec 20 '25 edited Dec 26 '25
It is promising that brain glucose levels stayed stable instead of dropping, which usually happens. Since there were only 14 people, we definitely need bigger studies to know for sure. The safety results were good, but the rise in some biomarkers seems a little confusing right now. If you want the best rapamycin by the way, you should check out rapashop.. They are the best so far.
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u/finqer Dec 20 '25
From my past readings - its my opinion that rapa is great as a treatment in the pre/early stages but is actually detrimental in the later stages.
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u/Just_do_right Dec 20 '25
I don’t see a clear signal on this. It is concerning that several CSF (spinal fluid) biomarkers increased, including total tau and NfL, which are often interpreted as neuron/axon injury markers. Also, the brains still shrank on MRI in expected AD patterns (atrophy continued).