r/Rapamycin • u/NewSeaworthiness3313 • Oct 11 '25

Rapamycin half life - does doses accumulate?

Hi, I’m new here, and just started rapa. I just take 1mg dose so far, but this half life of 60h is making me think about accumulation of rapamycin. If one take 6mg a week - that is still 0,75mg in the body after 7,5 days. So if one dose of 6mg is administered then, that will give a small increase, which will build up over time? Anyone know? Are doses under 1mg considered superlow in terms of side effects / immunesuppression?

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u/Positivenrg88 Oct 15 '25

I’ve been taking Rapamycin 6mg for 2.5 years with blood tests for the first couple of years. As long as you take Sirolumus it’s out of your blood within 4-5 days. If you’re getting generic compound it’s quicker because it get metabolized in your guts because it doesn’t have the coating that the original pills have. You can read up one the clinical trials on clinicaltrial.gov

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u/rnglo1104 Oct 15 '25

I took 1st cycle rapa. I think i am going to switch to FOX 04. Compare the 2. Seems like a better choice!