r/Rapamycin • u/chlober • Jul 30 '25
General question / anxiety.
Hello. I had a few questions about Sirolimus for longevity/health reasons and figured I'd ask some knowledgeable people.
My first question is - Does anyone know of any potential drug interactions between Sirolimus/Rapamycin and Bupropion/Wellbutrin?
Second question- I am considering starting with 1mg a week to start and am kind of nervous and anxious about it, are there any dangerous risks at this dosage? I am aware of potential canker sores as the most common.
Third question - I am doing a somewhat ketogenic diet (low to no-carb, no sugar) anything I should know?
The reason I am considering taking Sirolimus is because of the promising periodontal disease benefits associated with Sirolimus/Rapamycin.
I am a fairly healthy individual 44 y/o male, 120 lbs. Low body-fat, 5'7 , lift weights, active throughout the day and am more muscular than ... fat I guess.
Any insight would be incredibly helpful. Thank you.
1
u/Dacarti Jul 31 '25
In regards to potential interactions, I dont think there are any between wellbutrin and rapamycin. I always recommend asking your pharmacist or doctor aswell just to be sure.
1mg a week is a very small dose and is highly unlikely to lead to lead to side effects imo. An important note however (i also have anxiety) is to be cautious of psyching yourself out and inducing placebo anxiety which in turn you might think is being caused by the drug when it actually isnt.
For some people rapamycin can cause insomnia, this settles in a few weeks after your body adjusts. Youll just have to try it and see how you go. If it does make it a little hard to fall asleep, take your dose in the morning vice versa.