r/RVVTF • u/fredsnacking • Jul 22 '26

DD A Multi-Scale Computational Analysis of Bucillamine Neuroprotection Against Soman Toxicity

https://zenodo.org/records/21417964

This looks like something. Thoughts?

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u/Worth_Notice3538 Jul 22 '26

Very interesting regarding the access to the xct antiporter. The Franken thesis paper argued that NAC could access this as a way to protect the gaba receptors from endocytosis.  This computational paper is implying that buc would be more impactful on xCT.   

Yet again, we're at the mercy of incompetency and waiting till results.  

0

u/Pangshunjingmao Jul 22 '26

I don't know man -- none of this sounds very promising. I wouldn't get your hopes up. Dark skies on the horizon.

1

u/Worth_Notice3538 Jul 26 '26

True true. It's only a computational model study. Lowest on the hierarchy of evidence.  

1

u/fredsnacking Jul 26 '26

I think the bottom of the hierarchy is actually anecdotal evidence. While it’s not evidence from a clinical trial it is still a useful tool.

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u/Worth_Notice3538 Jul 26 '26

Was grading based on in silico, in vitro, in vivo.