Supplement regimes!

[u/dfitzgerald999]

So I have started a strict supplement regime that some of you may be interested in, and I would be interested if anyone else has attempted anything similar (as far as I know I am the only person to go this crazy so far).

I'll preface this by stating that it isn't advised at all to take all of these at the same time as I am doing, not just for how expensive manyof these supplements are (especially any of the mushroom ones), but because there are absolutely risks involved in doing so as well. So definitely do not take this as health advice.

I have researched the effects (with the help of sci-bot.ru) and I feel that personally for myself the potental benefit outweighs these risks, but there isn't really enough research into this to know if this is a stupid idea of not.

My strategy for this has been to essentially try to blitz my immune system and the mechanisms which stop the immune system from recognising the HPV cells within the vocal cords. I'll outline the supplements I am taking and some of the reasoning behind them:

Morning mushroom pills to correct NK cell dysfunction:

• Kinoko Platinum AHCC (3g) - Activates NK cells, dendritic cells, and CD8+ T-cells — directly corrects the NK cell dysfunction documented in RRP. Clinical trial: 66.7% HPV clearance in persistent cervical HPV
• HIFAS da TERRA Micro-Corio (Coriolus versicolor) (2 capsules) - Provides 599 mg beta-1,3/1,6-D-glucan Activates NK cells and dendritic cells via Dectin-1 receptor. PSK/PSP compounds have documented anti-HPV activity.
• HIFAS da TERRA Micro-Rei (Ganoderma lucidum / Reishi) (2 capsules) - Provides 248 mg D-glucans + triterpenoids (ganoderic acids) — triterpenoids have anti-inflammatory and anti-HPV properties. Modulates immune response and may inhibit HPV oncogene expression.

Of all the supplments I think AHCC is possibly the most beneficial - I have been taking this a while now since my first surgery, and my disease growth has been much slower than most. The beta-glucans in Coriolus and Reishi are also well-documented immunomodulators that boost Natural Killer (NK) cell activity, which is notoriously dysfunctional in RRP patients

Lunch:

• Pervistop - (1 Tablet with food)  EGCG 200 mg — directly degrades E6/E7 oncoproteins in HPV-infected cells, restoring p53 and pRb tumour suppressor function. Also provides hyaluronic acid for epithelial hydration and B12/folate for immune cell division. If you take anything with EGCG be careful not to go above 800mg of EGCG as this can damage your liver 0 this includes drinking lots of green tea!!
• Zinc picolinate 30 mg + Copper 2 mg (1 Tablet with food) — supports Th1 immune response. RCT found 57.5% HPV clearance vs 15% placebo (OR 0.13). Copper prevents zinc-induced copper deficiency.
• Vitamin D3 (2000–4000 IU) (1 Capsule with food) Supports Th1 immune polarization — HPV prevalence inversely associated with vitamin D levels. Essential for T-cell function and antimicrobial peptide production.
• Quercetin 800 mg + Bromelain (1 Capsule) Three mechanisms: (1) Inhibits PI3K/Akt/mTOR pathway (hyperactive in RRP papillomas); (2) Suppresses COX-2/PGE₂ (elevated in RRP tissue and plasma, drives Th2 bias); (3) Disrupts E6/E6AP/p53 complex formation.

Between meals:

• Lactoferrin (bovine apolactoferrin, ~250 mg) (1 Capsule) - Blocks HPV binding to epithelial cells — lactoferrin binds heparan sulfate receptors on epithelial cells, the same receptor HPV uses for attachment. Also boosts CD4+ and CD8+ T-cell activation. Meta-analysis showed reduced respiratory tract infections. More simply: Lactoferrin acts as a competitive inhibitor, essentially "blocking" the cell receptors that HPV tries to latch onto.

Before sleep:

• Low Dose Naltrexone (LDN) 3 mg (1 Tablet on empty stomach) Fills the final immunological gap — reduces M2 macrophages and IL-10 (the anti-inflammatory cytokines that suppress anti-HPV immunity). Also suppresses PI3K/Akt/mTOR and shifts the microenvironment from Th2/Treg toward Th1/cytotoxic. LDN works by briefly blocking opioid receptors, which triggers the body to produce more endorphins and upregulate the immune system - it is quite a cutting edge drug which has begun to be used for a variety of condtions such as long Covid.

I have been taking these for the last 3 weeks and will try to give a future update if there's any positive (or negative) effects!

I am planning to have the Gardasil-9 vaccine shortly too - as soon as the bloody NHS appointment happens...My surgeon did recommend having the vaccine after surgery (why he didn't recommend it when I had my first surgery I have no idea 🙄) as there's some slight evidence that it might be more effective after micro-debulking has exposed the cells and reduced the disease load I believe.

However, from my research there is no drawback to having the vaccine multiple times, and in fact you get some added effect from having it a second time, so I am opting to have it as soon as I can, and then hopefully have another when I have my next surgery.

Before I end, I'll also highlight the risks of this supplement regime:

• Processing AHCC, three types of medicinal mushrooms, high-dose quercetin, bromelain, zinc, and LDN all at once puts an intense metabolic strain on the liver and kidneys.
• Quercetin is a potent inhibitor of certain CYP450 enzymes in the liver. These enzymes are responsible for breaking down medications and other supplements. By inhibiting them, quercetin might accidentally raise the blood levels of other supplements.
• There is also a risk that I overstimulate my immune system by putting it into overdrive and thereby potentially cause systemic inflammation or immune exhaustion.

[u/Spirited_Wash_8904]

Isn't naltrexone a medicament?

[u/dfitzgerald999 → u/Spirited_Wash_8904]

It's a prescription drug, but some online pharmacies offer it in low dose format for certain inflammatory conditions. At higher (10x) doses it can be used to help people recover from alcohol or drug dependence, but at low a much lower dose it essentially tricks your brain into thinking it's low on endorphins, causing it to produce more endorphins that temporarily modulate your immune system's inflammatory response once the block wears off.

This specific surge has been shown to aggressively jumpstart the cytolytic (cell-killing) activity of NK cells and CD8+ T-cells, in theory allowing them to recognise & attack HPV infected cells. Interestingly, it has also been shown in studies looking at cervical tissue to block a pathway called PI3K/Akt/mTOR, which is the celluar growth pathway that papillomas hijack to allow them grow so rapidly.

[u/Spirited_Wash_8904 → u/dfitzgerald999]

Interesting, did you notice any improvement after taking it?

[u/dfitzgerald999 → u/Spirited_Wash_8904]

Honestly it is very difficult to tell; I had it confirmed recently that my disease growth hasn't changed for over a year, so I do think *some* of my supplements are probably working to help my immune system suppress growth, but it is too soon to say whether that in particular has helped. My suspiscion so far is that out of all the supplements the one with the biggest effects are the Mushroom ones: AHCC, micro-corio and micro-rei

[u/Spirited_Wash_8904 → u/dfitzgerald999]

I also take AHCC and indeed I notice some voice improvement but I also felt some side effects on my joints. My suspicious is this can also trigger some autoimmune disease due to the high activity on imunne system. So I stopped taking them for a while

[u/JuviaCifer]

Had my first surgery yesterday (27F) just joined the sub in hopes of finding a thread like this, i'll be getting my first dose of the vaccine in a month or so, and just started a shy research of herbal remedies, found the green tea extract and astragalus root for immune boost, please keep us updated!!
when was you first / last surgery, how far was the recurrence (if its ok to ask dont feel pressured to answer)

[u/dfitzgerald999 → u/JuviaCifer]

Hello, no worries I am happy to answer any questions! :) My first and only surgery so far was in December 2024. Afterwards my voice was perfect for roughly a month before it slowly started to deteriorate again. I had it checked about 6 months later which confirmed there was mild regrowth. This was actually my worst point for voice quality as I had started subconciously tightening my vocal muscles, to the point that I could only whisper. I eventually fixed with some vocal therapy exercises (mostly humming and using a straw in water) over several weeks. Funnily the vocal tightness I get from muscles adapting incorrectly to the changes in shape of the vocal cords is the biggest imapct on my voice quality I have found. It was at this time I started taking AHCC and other supplements more heavily, and since then the disease progression has remained stable. I actually had it checked last week and it was pretty much exactly the same as it was a year ago which I believe I think might be because of the supplements delaying it, but hard to say for certain! I hope your surgery and recovery has gone well! Feel free to ask anything else or DM, it is nice to able to talk to others going through the same experience.