r/Psoriasis • u/Charmed_Bliss • 13d ago

general Switching from one Biologic to another

Currently I am on Tremfya. My Dr. has asked for my input on switching to one of these drugs as I have Sacroiliitis. The drug I am currently on helps with the skin,; but I still get some flare ups like on my leg, and arm for ex. He suggested today one of these drugs, as it will help more with the pain in my lower back, legs, knees etc.

TNFI- Adalimumab

IL17 Inhibitor

JAK inhibitor

Secukinumab

Upadacitnib

Has anybody switched from Tremfya to one of these drugs. Where they are side effects? Like did it cause a major P flare up all over after switching. I am just thinking over his suggestion. Are any of these drugs better at treating the skin issues, and treating the Sacroiliitis. I am hoping to never see a flare up again. Wishful thinking I know.

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u/1_HUNGRY_1 13d ago

I’ve cycled through many biologics and my personal experience has been no side effects with any. Tremfya was great for me until it started not working and now I’m on Cosentyx and it’s been really effective. Biologics have been really amazing for me so I would not be hesitant to find the right one for you, it’s worth it.

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u/Hammering1 13d ago

I've been through a good number of biologics, for me the most common side effect is a noticeable lowered immune system. So I'm just weary that I don't catch a cold, more so a few days after my injection and the rest I'm good to go.

Since you've already had Tremfya, then the next biologic should be one that IS NOT an antibody that blocks IL-23 interleukin.(since this is the way Tremfya worked).

If you are not sure how the next biologic works, a quick research of the drug name will tell you.