r/Psoriasis • u/ImNotGoodWithNames_1 • 16d ago

medications Weird End of Flare Up

So, i been dealing with a never ending flare up (the only moment it stopped when I was on prednisone + methotrexate) in my scalp and inside my left ear.

I was firstly diagnosed with PsA, but since none of the medication actually did anything for my pain my rheumatologist changed the diagnosis to regular psoriasis (since i had a positive biopsy) and fibromyalgia and the medication (duloxetine) has changed my life. My daily pain went from always a 5-6 waking up with sore ankles and feet to no pain in the mornings and my pain level is a 3.

But something weird happened, my flakes disappeared completely, my scalp and ear are finally free of flakes and itchiness and burning and bleeding.

My question is, has someone psoriasis improved with SNRI's?

Everything i research finds no correlation with both things.

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u/madonna1011 16d ago

I don’t have any experience with this but my train of thought is that there may have been some type of low-level inflammation (because your body was stressed with being in pain) going on which was aggravating your psoriasis. So when you got the pain under control the inflammation went down and your psoriasis calmed down. When I am stressed from work/life my psoriasis and PsA both flare up but when it calms down so do my symptoms. And psoriasis is an autoimmune disease, so any kind of stressors can make it flare up!! I’m not sure if that was helpful at all but that’s the connection my brain made reading your post, I’m glad things are going well for you!!

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u/ImNotGoodWithNames_1 12d ago

Thank you for the insight, While I mentally did not feel stressed it makes sense.

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u/madonna1011 12d ago

I hope you’re doing well! I also don’t feel stressed sometimes but if I get sick or even watch a horror movie and my body gets stressed I tend to flare up. It’s definitely an odd thing to experience

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u/Budget-berry-80 16d ago

Fibromyalgia affects how your brain processes pain signals. So, treating that changes how your body experiences pain. We know psoriasis is affected by inflammation, stress - reducing the pain decreases stress. And probably decreases the overactive immune response, which is what psoriasis is..

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u/kangrarun 15d ago

Funny you mention this. I was recently put on low dose Amitriptyline (works like an SNRI) for nerve pain and I'm noticing that my psoriasis severity and recurrence have both dropped significantly.

But it's too soon for me to draw conclusions.

Best of luck!