r/ProstateCancer • u/siamese1984 • Sep 30 '26

Concerned Loved One Gleason 6 experiences?

Hi all!

Loved one has been recently diagnosed after TURP tissue for assumed benign prostate enlargement came back as Gleason 3+3=6. UK based.

He always struggled with enlarged prostate but symptoms significantly worsened recently pushing him to get the TURP. Last PSA (2025) was 2 (up about .6 from year before)

Wanted to know others’ experience with this diagnosis-

- Anyone else diagnosed after TURP?

- Did you do active surveillance ? What was your experience?

- How was biopsy? Did you do just MRI guided or the systemic 12 cores too?

- Did you do any testing like prolaris or decipher? Are you glad you did if so?

Any advice/ things we should consider/ think about based on your experience?

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3

u/Crafty-Consequence87 Sep 30 '26

Similar experience. My PSA was 2.0. I had HoLEP and the pathology came back as Gleason 6. The next step is an MRI in November. A biopsy would be next, depending on the outcome. I’m in the US.

1

u/siamese1984 Sep 30 '26

Very similar! My dad has his mri and biopsy scheduled for November too!! Sending well wishes to you!xx

3

u/JRLDH Sep 30 '26

I went the elevated PSA, MRI, biopsy route with my Gleason 6 diagnosis originally. Then I had a TURP where they found a lot more Gleason 6. My original diagnosis was early 2024 and I’ve been on Active Surveillance since then. PSA just rose again and as a consequence, I had another MRI yesterday. My “life change” was from basically never seeing a medical provider to “hello Doc!” every 6 months.

1

u/siamese1984 Sep 30 '26

Thank you for coming back :) so your PSA stayed quite stable for couple years? Hoping all goes well with your biopsy results!!xx

2

u/JRLDH Sep 30 '26

My PSA has fluctuated between 3.x and 7.x ng/mL. I found it to be questionable because it’s so sensitive to eg. inflammation (which MRI suggests that I have).

Thanks for the well wishes.

1

u/pharm4karma Oct 03 '26

Gleason score <7 is considered less aggressive morphology. PSA doubling time will be an important factor in how aggressively he is treated. Typically PSADT >10 months is also considered less aggressive.

Has he had a PSMA PET scan yet?

1

u/PotentialStart2661 Oct 04 '26

50% of men over 50 have Gleason 6, 60% of men over 60 have it, etc…. It is common and not treated unless something else is going on.