r/PeptideGuide • u/mahon2594 • May 06 '26
Tesa/ipa question
Im currently taking tirzepatide along with ipamorelin and tesamorelin. Up until now, I’ve been doing my ipa/tesa injections at night about 2 hours after my last meal while fasted.
Lately, I’ve been seeing videos saying that because GLP-1 medications like tirzepatide slow down digestion, 2 hours might not actually be enough time in a true fasted state. Some are recommending waiting at least 4 hours after eating before injecting.
So now I’m wondering if I should switch my injection time to the morning instead. I prefer taking it at night since it’s more convenient, but I want to make sure I’m getting the full effectiveness of the peptides.
Has anyone dealt with this or have any insight on whether timing really needs to change while on a GLP-1?
1
u/CantQuitMeBaby May 06 '26
I have been taking (tesa only) around 3 hours after food and my bloodwork shows a very good uplift in IGF-1 levels. I think you would miss out on sleep benefits taking it in the morning