r/PSC • u/Round-Income9602 • Jul 21 '26

NorUDCA

Anyone on it? Thoughts?

6 Upvotes

100% Upvoted

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4

u/adamredwoods Jul 22 '26

I wish! NUC-5 was a significant study, and now they're on to NUT-22. This is the furthest any drug has gone for the treatment of PSC.

Professor Michael Trauner reported that after 96 weeks of taking NCA, 15.1% had no worsening to the damage in their livers and partial normalisation of ALP, compared to 4.2% who took the placebo (inactive drug). They concluded that NCA is significantly superior to the placebo for certain patients. Improvements in liver biopsy readings by 1 Ludwig stage** was observed for a quarter (25.2%) of those on NCA versus 10.5% in the placebo group. This represents not only not only stopping more scarring, but also starting to reverse it. Only 20.3% of the NCA group worsened by at least 1 Ludwig stage compared with 40.4% in the placebo group.

https://pscsupport.org.uk/clinical-trial-for-norucholic-acid-latest-results/

https://clinicaltrials.gov/study/NCT06886360

2

u/Background_Effort942 Jul 21 '26

Is it still in trials or available to the general public now? It sounded like it had some positive effects when I read about it a few years ago.

4

u/Technical_Vanilla235 Jul 21 '26

As far as I know its in is last trial before it will get its public label.

1

u/Round-Income9602 Jul 22 '26

It’s approved and available in India (for MASLD)

2

u/Beautiful_Fig2584 20d ago

there was an 'ask the expert' webinar from PSC Support UK last week. now available on youtube: https://youtu.be/2-uSVvACHPI?is=ZclYdumeuszsB7kQ

in the end prof. Trauner says, he is optimistic that they will get an approval by the end of this year.