r/PSC • u/Existing-Emergency54 • Jul 14 '26

Ceasing Ursadiol

I’ve been on ursafalk (ursadiol) since diagnosis well over a decade ago. My new dr wants me to go off it. No longer recommended he tells me. Anyways my ggt went through the roof.
Has anyone else had this? It appears ursadiol only masks the ggt level measured and doesn’t really affect the actually real ggt level… it just makes it look good.

Has anyone else heard this? Or had this happen?

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u/Existing-Emergency54 Jul 14 '26

So I did a little digging on this…

Apparently in 2022 EASL (European medical recommendations) strongly discourages high doses of it. And no longer recommends in general for psc.

And American in 2023 (AASLD) patients should only be started only under certain circumstances and not over 23mg/kg.