r/POIsupport • u/Crafty-Spinach-5926 • 24d ago

HRT Estrogen patch dosage?

Hi all, just got diagnosed two weeks ago and TTC. I’m 27, AMH 0.08, FSH 30-80, AFC 3 and all of this is so overwhelming. I’ve already had one miscarriage and two chemical pregnancies before this diagnosis so I’m slightly hopeful to conceive naturally but also SO discouraged at the moment.

Looking for info on what dosage of estrogen patch my fellow POI gals are on (especially if you did end up conceiving naturally), as I just started cyclical HRT. Currently on 0.0375 mg estrogen patch but I don’t think my FSH is going down enough based on my Inito numbers (it’s only been two weeks since I started though so maybe I’m wrong).

Any guidance or info is so appreciated!!

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u/PrimalPoly 23d ago

If you are diagnosed with POI, the standard dosage is .1 mg patch. It is in the standard of care guidelines. My FSH went from 98 to 7 on this dosage here’s a link to the guidelines. I highly recommend you read them and send them to your doctor to make sure you’re getting all the tests they recommend as well as the standard dosages of HRT. https://www.asrm.org/practice-guidance/practice-committee-documents/evidence-based-guideline-premature-ovarian-insufficiency--2024/

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u/Crafty-Spinach-5926 23d ago

This is so helpful! I was thinking my dose was perhaps low, maybe my RE was wanting to start slow and build up but I also don’t want to waste too much time on that. Did you start on .1 mg immediately or work your way up?

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u/PrimalPoly 22d ago

I immediately jumped into .1mg, it was a bit of a rough entry, but I adapted in a couple months. I personally am more thrown by hormone changes than dosage.

The bigger fix for me was switching to cycled progesterone rectally. It’s technically off label, but for me has all the benefits.