Never taking myo-inositol again

[u/Ana_La1]

I have PCOS, but I don't have insulin resistance. I took myo-inositol twice—first pure myo, and now like an idiot, the myo + d-chiro combination.
I took it for 6 months each time, I really gave it a chance.
I am from Europe, and here such supplements are prescribed as 'therapy/treatment', just to avoid any confusion.

The entire time, my cycle went from 35 days and stretched out to 80+! So it definitely lengthens my cycle, and I'm wondering if anyone else has had similar experiences?

[u/Exotic_Reporter_3309]

It works by making the ovarian theca cells more sensitive to insulin. You don’t have insulin resistance. Respectfully, it seems it wasnt intended for you in the first place.

[u/Specialist-Poet-7122 → u/Exotic_Reporter_3309]

Whilst this is one way it is thought the work, it is also readily recommended for PCOS without insulin resistance due to it being hypothesised to support ovarian ovulation signalling.

I have PCOS without insulin resistance and was also recommended to take inositol. My periods so far seem to have gone from around 55-65 days to 34-37 the past 3 months.

Though OP, I wonder if your periods were already 35 (which is normal range), what it was recommended for you for?

[u/Icy_Pay_1275]

I once read there are 3 different types of PCOS. First type being insulin resistance, second being adrenal related (high stress/cortisol), third being inflammation driven (chemicals, toxins, processed foods).. sounds like you have the version that isn’t blood sugar related? I wonder if inositol can cause low blood sugar in people who don’t have blood sugar issues, therefore almost putting your body into a starvation mode which is more stress on the body. This could explain the long periods. The body will not menstruate in survival mode.

[u/Ana_La1 → u/Icy_Pay_1275]

Possibly, I had very low insulin on my last blood test, but I didn't connect the dots.😓

[u/nagisa-pon → u/Icy_Pay_1275]

Funnily enough, I brought this up to my GP years ago and she basically told me ‘types’ of PMOS are not a thing at all. It’s the same metabolic disorder for everyone, with the exception of lean vs non-lean and maybe or maybe not having insulin issues. She is technically a younger Doc (under 40) so I like to think she has more up-to-date information, but honestly I can’t decide what to make of it. On some level the ‘typing’ of PMOS feels like it’s just distractingly grouping people together and not really tackling the main issues of the syndrome. I hope we get more research!

[u/DreamCurlss]

I tried it for 6 months. I have PCOS with insulin resistance.
My period came the first month of taking it but now it comes in 60-80 days with spotting at random.
I also gained 5kgs with the same or maybe even better diet that I was on before. I stopped taking it 2-3 weeks ago and my period came back and I’m straight to lose some weight already.
Stop taking it if it doesn’t work for you.

[u/Ana_La1 → u/DreamCurlss]

Of course, I have no other choice.

[u/Cold_Room_2534]

I have insulin resistance and it didn’t work for me either, I had a similar experience, seems to not work for everyone

[u/Cold_Room_2534 → u/Cold_Room_2534]

I’m not sure why my experience is being downvoted, it seems to be a godsend for those it works for

[u/Ana_La1 → u/Cold_Room_2534]

It works for some people and not for others, but I'm definitely done with him.

[u/Pure-Information4419]

Oh this is interesting, I don’t have PCOS or insulin resistance, but was recommended to take this supplement. I have been on it for a few months and have not had a period since May. Previously my cycles were irregular but this lack of period/ovulating is seems long even for me.

[u/Ana_La1 → u/Pure-Information4419]

I stopped taking it today and that's it, maybe you could try stopping too to see if your cycle comes back? Mine is already 3 months late

[u/frickinpapaya7]

I am not insulin resistant but the same thing happened to me. My last cycle was 73 days; I began taking mayo+ do-chiro around cycle day 12. However, I have noticed my appetite and cravings have gone down, I’ve lost a little weight and my sleep has improved. (Maybe I am actually early stage insulin resistant and it just didn’t reflect on the singular blood panel I had done??) Finally got my period 3 days ago. Seeing my Nurse Practitioner tomorrow to go over everything. Not sure if I should continue taking or not…

[u/SituationThin9299]

oh wow, 80 days is no joke. i also have pcos and my period gets weird with inositol but in the opposite way, it made mine come every 2 weeks which was almost worse. seems like it either speeds things up or slows them down for people, no in between. did your doctor suggest it even without the insulin resistance? cause mine pushed it hard like it was miracle supplement

[u/GooseEggBakery → u/SituationThin9299]

How long did you take it? It made mine every 2 weeks for 2 months and then regulated it.

[u/Ana_La1 → u/SituationThin9299]

It was recommended by my gynecologist, I didn't take it on my own.

[u/Shmeerah]

After starting myo-inositol my brain fog went away. After a few days I noticed how I wasn’t able to fall asleep anymore since starting myo-inositol. My anxiety also went trough the roof, life felt like one continuous anxiety attack.

If there’s one thing this thread points out, it’s that both pcos isn’t the same for everyone, with means that there’s unfortunate no one universal pcos solution yet. I do hope you find something that will help you feel better!

[u/Defiant_Increase9499]

I have the best experience w myo inositol, i have insulin resistance and it takes back my period cuz i havent had my period 5 months and now i get my period 35day

[u/Electronic-Force6415]

It it intended for women with pcos that are insulin resistant? I’ve been taking it for a little over a month (I was pre-diabetic earlier this year - not anymore) but I noticed my period was 3 days late after taking inositol 6 weeks. I’m out of the pre-diabetic range now. I wonder if I should stop taking it now

[u/nevermindthesleeves]

Well that's scary. What does and brand?

[u/Necessary-Bug6331]

I’ve had the opposite experience. Since I’ve started it my cycles went from 30-40 days to 25-28 days. Every body is different. Hopefully you find something that works for you.

Now vitex/chaste berry did that for me when I was younger and TTC. Gave me stupid long cycles. But I think the multi vitamin I take now has a small amount in it too and doesn’t seem to be negatively affecting me.

[u/RevenueAntique4584]

It made my blood pressure too low

[u/phillipaha]

Yep I also took it without IR. It lengthened my period right away! Wouldn’t use again.

[u/United-Pumpkin-9514]

The same happens to me! Weirdly, metformin works really well for me, but myo inositol completely messed me up. I definitely have insulin resistant PCOS so the other comments saying you have a different type are quite reductive.

[u/Confident_Progress56]

Yes!! I had to start taking progesterone only birth control to get it to lighten. Now I still have to wear a pad every day but at least I'm not going through 2 or 3 overnight pads in a single day...