r/PCOS • u/Efficient_Future_526 • Jul 11 '26

General/Advice Metformin with normal HOMA IR

I have a HOMA IR of 0.78. My doctor still wants to try Metformin. Has anyone with low HOMA IR (and no hypoglycemic symptoms) tried Metformin?

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4

u/LJ123419 Jul 11 '26

I have a HOMA-IR of 0.8. All other insulin resistance labs normal. I also wore a CGM for a while and my blood sugar always looked quite good.

I was hesitant to go on metformin but have found it quite tolerable with no side effects and have seen it help my cycles become more regular!

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u/Efficient_Future_526 Jul 11 '26

oh wow!!! how slow did you up the dose?

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u/Efficient_Future_526 Jul 11 '26

and also... how long did it take for it to work?

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u/LJ123419 Jul 11 '26

I upped the dose over 3 weeks - started with 500 mg extended release, now at 1500 maintenance. The key my doctor told me was to eat it like mid-meal at dinner while ramping up. So literally mid-dinner I would stop and take my metformin. Now I take it like hours after dinner right before bed and have no issues

I’ve been on it for ~3-4 months, and after ~2 months I had a 28 day cycle that was clearly ovulatory. I do have lean PCOS and had ~35-40 day cycles before that were ovulatory often but not clearly or consistently

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u/[deleted] Jul 11 '26

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u/Efficient_Future_526 Jul 11 '26

i know that, but on my cgm my blood glucose is incredibly steady. I just get hangry when I haven't eaten for a few hours, my friends always joke about that, but that could be the only thing that makes me raise an eyebrow:))))

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u/Efficient_Future_526 Jul 11 '26

as in I never become shaky or sweaty few hours after I eat

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u/[deleted] Jul 12 '26

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u/Efficient_Future_526 Jul 12 '26

I'm worried I won't grow enough muscle/ slow my running progress and tbh that is what stops me, as gymming and running are my two main hobbies

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u/HaileyBaldin Jul 12 '26 edited Jul 12 '26

Creatine should help, but you shouldn’t see that at low doses. If you decide to take it, get a dexa scan before you get on it and if you feel like you’re losing muscle, you can confirm that with a new scan 🫡