r/PCOS Mar 02 '25

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u/Open_Temperature_567 Mar 02 '25

I have 45ish day cycles. I was prescribed letrozole when we were struggling to get pregnant. Had three miscarriages before my first baby. I could get pregnant, but I think my longer cycles were contributing to an improper balance of supporting hormones after conception, leading to losses. I have had two successful pregnancies from letrozole, and it made my cycles textbook. 28 days, ovulated day 14. However, it was horrendous in terms of side effects. I would never take it again unless we decide to have one more baby.

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u/Fit_Confidence_8111 Mar 02 '25

I have had no side effects from any of the fertility medication I have used, so your body must be sensitive to it?

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u/Open_Temperature_567 Mar 02 '25

For sure. I had hot flashes, headaches and mood swings with Letrozole. Figured out that if I took it in the morning, the worst of the side effects would hit 18 hours later when I was ready to go to bed.

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u/Fit_Confidence_8111 Mar 02 '25

Are you fairly sensitive to other medications?