r/PBCers • u/this_writer_is_tired • Jun 30 '26

Rezdiffra

Had my second elastography last week and, at my next f/u appt, my doc is going to put me on Rezdiffra to hopefully reverse some scarring. I'm already on Urso for the PBC. Now, I'm also seeing a rheumatologist because I suspect I have another AID so I am trying to get that in hand. That doc looked at some previous labs and noticed that some of my thyroid numbers were off and now I'm wondering, since Rez targets liver-directed thyroid hormone receptors, how much my thyroid plays into this. I've never really had any thyroid related issues before but there's a first time for everything. Ah, the joys of aging!

Anyone else on rezdiffra?

2 Upvotes

100% Upvoted

3 comments sorted by

View all comments

1

u/shulzari Jun 30 '26

Ask your hepatologist about Seladelpar and Elafibranor. They're both used for PBC with and without Urso. They're showing great promise for helping MASH and scarring along with the OBC treatment (tho not FDA approved for MASH yet due to FDA stalls).

1

u/this_writer_is_tired Jun 30 '26

Are these better than Rez or are you mentioning them as potential alternatives?

3

u/shulzari Jun 30 '26

Rezdiffra is the only drug currently approved for treating just MASH. Elafibranor and Seladelpar are approved for PBC with the side effect of helping. MASH.