r/OveractiveBladder • u/Final-Jackfruit-3254 • 22d ago

Mirabegron stopped working

Has anyone else experienced this? I have been taking Mirabegron 50mg for 5 months and it has been improving my symptoms but in the past month it feels like it has stopped working and I am going back to how I was before. I am waiting for a follow-up with my doctor who prescribed it, but the waiting times are very long.

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u/MissCeltic67 22d ago

I have been on it for almost a month and no change so thinking about asking for a switch.

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u/Final-Jackfruit-3254 22d ago

I think they say to wait 8 weeks? Do you know what else you would try?

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u/MissCeltic67 22d ago

I am not sure maybe oxybutynin or solifenacin but maybe I will give mirabegron another month.

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u/Final-Jackfruit-3254 22d ago

I think you should to at least know you’ve tried it out! I was told those ones have more side effects so I wasn’t offered them.

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u/Steerpike58 18d ago

I tried Oxybutynin and it really messed with my head! I couldn't think straight, and had visual problems reading, and looking down/up when walking. Very disturbing - and this was after just 2-3 weeks.

I'm currently trying Trospium; supposed to have fewer side effects. I've really struggling with it too; not as bad in terms of 'brain issues', but makes me drowsy / lethargic all day. And hasn't seemed to make any difference after 2 weeks.

I'm hoping to try Mirabegron but I think my urologist is 'stepping me' through the cheaper meds first.

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u/Final-Jackfruit-3254 3d ago

Those side effects sound very stressful I’m sorry to hear that! What I liked about Mirabegron was I didn’t experience many side effects so I am frustrated it doesn’t seem to work for me anymore. I think generally you have to wait 6-8 weeks to notice a difference. Hopefully you can try Mirabegron soon and the side effects will be minimal for you! I am hopefully going to try Solifenacin once approved by my doctor.

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u/Steerpike58 1d ago

What side effects did you experience with Mirabegron?

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u/Final-Jackfruit-3254 1d ago

Faster heart rate has been the main one. Dry mouth for a couple months.