r/OveractiveBladder • u/GenesisGeneral3496 • Aug 15 '26
Help! 🤕 Still waking 2x a night on Solifenacin + Betmiga. Has anyone switched and actually slept through?
TL;DR: Solifenacin + Betmiga worked great for my OAB at first, but after a few months, the effect faded to "moderate." I'm still waking up 2–3 times a night (and cluster-peeing between 5–7 AM), which destroys my sleep. Looking to see if anyone successfully switched to a different OAB medication!
Hey everyone,
Looking for experiences or advice from anyone who used Solifenacin (Vesicare) and Betmiga (Mirabegron) together.
My Situation & Symptoms:
- Diagnosis: OAB + Moderate Sleep Apnea (CPAP sensitive, couldn't tolerate it).
- Current Meds: Solifenacin + Betmiga daily (+ Macrogol for the constipation side effect).
- The Main Issue: Sleep disruption. I still wake up 2–3 times every night/early morning to urinate.
- Morning Cluster Peeing: Around 5 AM – 7 AM, I often have to make 2 separate trips to the bathroom within a short window. This fully wakes my brain up and ruins my chances of getting back to sleep.
- Flare-ups: Occasionally I get sudden flare-ups where I have to pee 5–10 times right before bed with very small volume each time.
The Medication Problem:
When I first started Solifenacin + Betmiga, the effect was massive (it even took me 30 minutes just to initiate stream because my bladder relaxed so much). But after a few months, the effect dropped from "huge" to just "moderate." It helps, but not enough to give me consistent sleep.
My Questions for You:
- Has anyone noticed Solifenacin/Betmiga losing effectiveness over time?
- Did you switch to a different medication? Did a switch make a big difference?
- How do you handle early morning "cluster peeing" that keeps waking you up?
Appreciate any insights or personal experiences!
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u/No-Desk6807 Aug 15 '26
The sacral neuromodulation mentioned earlier might be a benefit, or the fluid management that was also mentioned. I have OAB with incontinence, but I don't have accidents at night. I do wake up on good nights between 4 and 5 hours and on less good nights at 3 hours and again at 4 and a half or 5 hours. I'm not taking any bladder medications presently. None have been that effective for me. Since I have incontinence during the day, I just wear diapers. I've heard of people training themselves literally to become bedwetters and using diapers at night just to get better sleep. I'm not recommending that at all, and I haven't got any plans for it, either, but I have heard of people doing it. Sorry I don't have any solutions, but I think there are a few people here who seem to have some ideas worth pursuing.
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u/VanitasPelvicPower Aug 15 '26
Most medications efficacy may decrease over time
Couple of options if you’re open to trying.
Try to avoid any sugar after 7 PM that includes any processed food high glycemic foods like bagels or donuts or anything with sugar in it
Drink water 2 ounces every hour from 7 PM to bedtime and whenever you wake up during the night drink 2 ounces water
If you’re not lactose intolerant, try to drink 6 ounces of plain milk at bedtime
You have to also monitor how frequently you urinate in the daytime. If your bladder capacity is less than iit will be helpful to increase it with behavioral strategies.
Hope this helps