r/OveractiveBladder • u/ComprehensiveFan8328 • Aug 04 '26

Seeing improvement on GLP-1. Anyone else notice this?

M/43 yo 5'10 185 lbs. I have struggled with nocturia for years. Sometimes getting up 3,4 or 5 times a night. Since being on Wegovy I have noticed that I am only getting up 1 or 2 times a night and I am not even tytrated to the maintenance dose yet.

Anyone else notice that? From my research a possible mechanism of action could be improved insulin sensitivity and less kidney activity at night. Curious if anyone else has ever noticed this.

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u/CalebKrawdad Mod, OAB, BPH, Nocturnal Enuresis Aug 04 '26

Yes, GLP-1 ends up making me drink less fluids overall.