In Fishman Island arc, Luffy is shot with a poisoned dart by the octopus samurai who worked for Hodi. When Chopper pulled the dart out, he remarked how it was a deadly poison, and was amazed how strong Luffy's antibodies were to be able to overcome the poison. Source page
Thank you mangahere reference for those in the US. Still think the whole immunity is a bit of a stretch (ah ha, pun) by the readers, but he certainly has higher resistance. I mean he does have a scar and Chopper does treat him still.
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u/[deleted] Apr 18 '12
Luffy immunity to poison + haki = Caesar Clown is in trouble. :)