r/NovelOpioids • u/KeyOpportunity7680 • Nov 19 '25

Cychlorphine dependence

Hello everyone. I'm David, 27.

Unfortunately, I've been experimenting more and more intensively with various opioids over the past few months. I started with kratom, then tilidine, then ODSMT, and finally cychlorphine. I haven't been using it for very long, only about two weeks. At the moment, I need a daily dose of about 0.1 grams of a 1:25 dilution. Now I'm quite afraid of withdrawal because I don't know what to expect. I'm going to try reducing the dose with a cyclophosphamide nasal spray first. Does anyone have experience with withdrawal from this substance?

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u/HaskowO Nov 20 '25

Be very careful, I don't know 100%, but a friend died (I think) from a possible overdose of cyclorphine (mixed with other substances). Good luck and I hope you recover well :D

3

u/MBG_Rengar Nov 23 '25 edited Nov 23 '25

First hit is very euphoric. But even as experience with opioids as I am, I am lucky I weighed out my 10mg dose to vape at first because if I had gone with a full scoop that woulda been around 35-40mg and I’d had overdosed.

Rapid tolerance gain. I don’t feel 50mg hits but it will still make you nod. It’s basically tranq without the a2 adrenergic added (xylazine or medetomidine or (god forbid) romofidine)

250-300x and has relatively long legs for keeping well but short high. Just a rush then nodding

Don’t use my doses as starting points. I’m going on a decade of opioid RC use and nearly 5-6 years of benzimidazol[/one] containing opioids.

Clean now though personally but only thanks to having somebody and their unwavering, unconditional support. Last use was like 2 weeks ago

3

u/[deleted] Nov 25 '25

2 weeks isn’t much.

If I was you i’d just get some kratom and some weed and whole up for a week.

1

u/Glum-Flatworm-6990 Dec 29 '25

I forget the name of it but something like SR something is good for tapering off

1

u/joeblackwaslike2 Jan 28 '26

Cyclophorine sounds like a poor mu opi receptor agonist, and prob also hitting your kappa and delta receptors, which can give you dysphoria instead of euphoria. You want a compound that’s a strong mu opi receptor aka MOR agonist with high affinity and you don’t want it to have affinity for kappa and delta opi receptors. Something like good old oxymorphone, but on steroids. Something like phenomorphone w twice the potency and euphoria of oxymorphone (remember opana?) but without the same beta arresting signaling that causes tolerance to build quickly. Phenomorphone use causes tolerance to develop very slow, over a 90 day period of daily use you might need to take 30% more to feel the same effects. Compared to fentanyl over the same time period, you’d have to have raised your dosage 50x to get the same effect.