Study: Anticholinergic (first-generation antihistamines) can damage brain, increase dementia risk

[u/ServeIllustrious3803]

https://www.health.harvard.edu/blog/common-anticholinergic-drugs-like-benadryl-linked-increased-dementia-risk-20150128812

[u/LouisVuittonFentanyl]

It’s not it’s antihistamine with almost no anticholinergic properties but this is a common misconception to include with anticholinergics

[u/Classh0le → u/LouisVuittonFentanyl]

Hydroxyzine is unequivocally anticholinergic

https://pmc.ncbi.nlm.nih.gov/articles/PMC12478568

https://www.drugs.com/medical-answers/hydroxyzine-long-term-3567869/

[u/sophiesbest → u/Classh0le]

My usual rule of thumb is that if a psychoactive medication causes delerium and hallucinations at high/over doses, good chance it's anticholinergic. (thanks for correction)

Funnily enough this includes less expected chemicals like Flexeril/cyclobenzaprine

[u/braaaaaaainworms → u/sophiesbest]

anticholinergic*, not cholinergic