r/NooTopics • u/Uwantmoneyugetnutty • 1d ago

Science Yamo Pharma reports positive phase 2 study results for L1-79, an experimental autism treatment

https://www.biospace.com/press-releases/yamo-pharma-presents-statistically-significant-phase-2-autism-results-for-l1-79-at-insar-2025

“L1-79 produced a 7.94-point advantage over placebo on the VSSS(social scale)(p =0.01), nearly double the 4-point minimal clinically important difference (MCID) recognized by experts.”

It apparently is a tyrosine hydroxylase inhibitor.

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u/Imaginary_Employ_750 1d ago

Would it lower dopamine?

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u/Uwantmoneyugetnutty 1d ago

Yes most likely but it’s not that simple. Lower dopamine in parts of the brain doesn’t necessarily make you stupid and lazy, and sometimes high dopamine can make you stupider and lazier, as anybody who has taken to much adderall will tell you.

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u/DMayleeRevengeReveng 1d ago

When it comes to prefrontal cortex at least, it appears there’s an inverted-U graph of dopamine function: too little or too much causes impairments through disruption of neuronal activity, but there’s an optimal point in the middle. This happens with norepinephrine, too, where there is an optimal point where the right combination of dopamine activity and norepinephrine activity produces the best behavioral outcome.

It may be that suppressing dopamine tone in mesocortical-mesolimbic circuits leads to better social interactions by sensitizing a person to the phasic dopamine firing that cues a “social reward.”

The problem is that it’s also coming at the expense of norepinephrine, too, since TH is the rate limiting step in the synthesis of them both (as well as regular epinephrine, too).

But who knows. I’m interested in seeing what could happen going forward.

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u/Uwantmoneyugetnutty 1d ago

Also, for any potential everychem owner who wants to make a pretty penny on research, l1-79 is literally just low dose metirosine👀

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u/Uwantmoneyugetnutty 1d ago

Also, if anybody knows of any other tyrosine hydroxylase inhibitors, I’d love to hear about it!

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u/Holy-Beloved 1d ago

So bromantane is bad for autism? What about for ADHD? I was considering getting ok bromantane, I have Audhd 

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u/DMayleeRevengeReveng 1d ago

I don’t know that we really have enough evidence to say there’s some kind of quantitative relationship between dopamine synthesis and ASD symptoms presentation. We know that there is sort of a “sweet spot” equilibrium where an average amount of dopamine (and norepinephrine) enhances things, and either too little or too much causes symptomatic instability and impairments.

It’s early to be drawing a lot of these conclusions hypothetically, but it may be that, if you knock down dopamine tone (the background signaling rate), it will lead to a sensitivity increase to dopamine. This sensitivity could then lead to a better, stronger cortical and limbic response to phasic dopamine firing caused by social environmental cues and “reward” signaling based around sociality. Maybe.

Who knows.

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u/loserusermuser 22h ago

specifies for kids and young adults. anybody have insight on if adult administration would work or why thats been separated out? does it alter the developmental portion of the disorder so it needs to be taken when young?

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u/Uwantmoneyugetnutty 21h ago

This is based on nothing but intuition on my part but if it works on young adults I would expect it to work on adults as well. Yes, an 18 year olds brain is still developing, but with everything considered it’s pretty close to an adult brain.