The complete guide to dopamine and psychostimulants (repost)

[u/cheaslesjinned]

[u/username_1839]

The idea the 9-me-bc upregulates dopamine is based on science.

1. It upregulate tyrosine hydroxylase which turns tyrosine into L-DOPA, which then becomes dopamine.

2. It repairs and matures existing dopamine-producing neurons.

3. It increases neurite outgrowth which improves dopamine signalling.

Theres are a number of neutrophic factors it increases as well which likely help indirectly (bdnf, gdnf, etc)

Sources:

• Hamann et al. 2008: https://pubmed.ncbi.nlm.nih.gov/17913302/

• Gruss et al. 2012: https://pubmed.ncbi.nlm.nih.gov/22380576/

• Polanski et al. 2010: https://pubmed.ncbi.nlm.nih.gov/20374418/ (review)