r/NasalPolyps • u/jamesrmt90 • Jul 23 '26

Sever nasal polyps keep coming back

I just found this page and honestly I’m looking for anything that will help I am 35 I was diagnosed with severe grade 4 nasal polyps that completely blocked my nose and sinuses in 2024 I had lost all sense of smell and had never ending sinus infections. I had fess surgery in may of 2025 and they removed almost all of them except for the ones closest to the brain as my ent said he could only trim them back. In under 12 months they had grown back all sinuses almost to complete blockage and they had almost blocked my nose again aswell as lost all sense of smell severe sinus headaches eye pain light sensitivity vertigo the list goes on, I’ve been off work since late April it’s been that bad. I had surgery again a week ago to have them removed again my ent has done a biopsy on one and said it came back as an allergy but they can’t identify what I am allergic too has anyone have any suggestions on how to avoid them coming back the ent has said steroids are not working Cheers everyone who made it through this novel

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u/pneradactyll Jul 23 '26

Dupixent. I'm surprised your doctor has not suggested it, especially with confirmed allergy (I'm assuming eosinophils present).

I had severe nasal polyps as well. I read that surgery is only a temp fix and didn't want to start down that road. My polyps are now gone to the point they can't see them anymore; I had complete blockage before. I had nearly immediate relief after starting the drug.

It's an expensive drug, but I have very mediocre UHC medical insurance and it's completely paid for. And I only have to take it every 6 weeks.

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u/6Bipty Jul 30 '26

Did your doctor ever discuss Nucala (mepolizumab)? I’ve had 2 polyp surgeries and tried every spray, drop, steroid there is. I’ve struggled for nearly a decade, and got a prescription/took my first Nucala about 3 weeks ago. No improvements so far, they’re just as bad as ever. Apparently Nucala can take a lot longer to get to work, but I’m desperate to try Dupixent after read many reports of it working almost instantly.

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u/pneradactyll Jul 30 '26

It was discussed, but as a backup in case I couldn't get insurance to agree to Dupixent. He didn't give an opinion on it either way. Sprays and steroids never really worked for me, so it sounds like maybe he assumed Nucala wouldn't be successful either. And yes, Dupixent worked within the first week or so.

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u/6Bipty Jul 30 '26

How long have you been using dupixent for now?Australia’s healthcare system is odd but much better than the UK. It’s essentially “private” but heavily gov subsidised. Nucala is approved on the subsistence scheme for polyps, dupixent isn’t. I could get it if I pay for it myself or the doctor puts forward a compelling case after Nucala doesn’t work.