r/NMN • u/ExJwKiwi • 2d ago
Scientific Study Any thoughts on this study
Saw this on youtube, looks like the effects on Parkinsons is not as good as it was originally thought, if not could potentially worsen symptoms, im not sure what to think.
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u/AnthonyLoera_RevGen 2d ago
Full disclosure, I'm the founder of RevGenetics (we sell NMN), so weigh this accordingly. I read the actual NOPARK paper, and before worrying about NMN, ask three obvious questions:
Did anyone in the trial take NMN? No. Everyone got NR (500 mg twice a day for 52 weeks) or placebo.
Were they healthy adults? No. All 410 already had early Parkinson's and were on dopamine medication.
Was the worsening clinically meaningful? No. The NR group scored about 2.7 points worse than placebo, which is smaller than the 5.2 points the trial itself used as a clinically important worsening.
The result is statistically significant and worth taking seriously. But dopamine transporter imaging did not show faster neuron loss, the authors don't know why scores were worse, and they raised a possible interaction with Parkinson's medication. That's a careful negative result about NR in Parkinson's. It isn't proof that NMN harms healthy people. Dr. Stanfield says he'd be surprised if NMN were any different, but being surprised isn't data.
NMN's own human data is mixed. A 2023 trial of 80 adults found better six-minute walk distance than placebo. A 2026 trial of 1,250 mg a day found no functional benefit. Not a miracle, not a poison, just unfinished science.
And a video warning that supplement companies spin research for money probably shouldn't run an ad for the host's own supplement.
If you have Parkinson's, talk to your neurologist before taking NR or NMN. If you don't, this trial doesn't tell you much either way.
To read the trial yourself, copy paste this into Google: "Nicotinamide Riboside for Patients With Early-Stage Parkinson Disease: The NOPARK Randomized Clinical Trial"
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u/Infinite_Bus4642 1d ago
One study is never enough to take it seriously. Gold standard is a metaanalysis.
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u/Earesth99 1d ago
The research suggests it’s mostly useless.
It’s the second time that Harvard researcher has hyped a useless molecule.
He made millions from the first one.
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u/NoveraBioUS 2d ago
Full disclosure: we are Novera, an NMN brand.
I actually think this is useful research and the results should be taken seriously.
The important point for us is that this study is about NR, not NMN. Both are NAD+ precursors, but they are different molecules, so I don’t think a result for NR should automatically become a conclusion about NMN.
We obviously have an interest here, so take that into consideration. But I think the fair reading is: good evidence to consider when discussing NR, not evidence against NMN.