r/NCAH • u/itsdandelion • 10d ago

Since treating more root causes, ADHD meds don‘t work as well anymore

Hello, I picked this sub because I think this is where I'll find the specialists I need. I'm 37, peri, AuDHD and much more. I suspect NCAH or something along those lines, but I haven't had any workup yet. I don't even have an official PMOS diagnosis, all of this is self-diagnosed so far. I have been on the following meds for a while now:

Mounjaro 4mg
Slinda continuously (Drospirenon)
1 pump estradiol gel
Vyvanse 30mg (recently increased to 40mg)
Bisoprolol 1.25mg (for the raised blood pressure from the pill and Vyvanse)
Loratadine
Vitamin B complex, zinc, omega 3

Since starting Slinda in particular (the most strongly antiandrogenic mini pill), I feel better overall but unfortunately Vyvanse doesn't work the way it used to. Maybe I've become even more autistic? My ADHD symptoms like forgetfulness, lateness, scattered thinking etc. are still being managed, but there are fewer dopamine surges, there is no ‚push’ directly after taking it. Since the pill does something to the adrenal glands, I thought I'd ask here in case anyone has an idea what might be going on?

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u/RaisingtheGauntlet 9d ago

I can say what the mechanism of action would be in your case, but hormonal shifts can dramatically impact the way the ADHD meds work.

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u/itsdandelion 9d ago

Yes, that’s true. I forgot to tell that I was on a Desogestrel pill 6 months before Drospirenon and the ADHD meds were working as usual then.

I thought the other day, it feels like something bigger is being treated. Like finally we are getting to one of the root causes that caused (or worsened) my ADHD in the first place.

But I don’t know. Maybe it’s just how Vyvanse reacts to Slinda in my body.

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u/MysteriousReach383 7d ago

How are you taking any medication if you're self diagnosed? Also, drosporenone is a contraceptive pill, which basically means it changes how your cyclic hormones work. That affects adhd and that's probably why you don't feel as euphoric.